Chang Yuqing, Zhao Wei, Li Wei, Zhang Qiang, Wang Guodong
Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, PR China.
Department of Stomatology, Changzheng Hospital, Naval Medical University, Shanghai 200003, PR China.
Int J Biol Macromol. 2024 Sep;276(Pt 1):133858. doi: 10.1016/j.ijbiomac.2024.133858. Epub 2024 Jul 14.
Recurrent oral ulcers are common oral mucosal lesions that severely reduce patients' quality of life. Commercial mucoadhesive films are easily disrupted due to oral movement and complex wet environments, thus reducing drug utilization and even causing toxic side effects. Herein, we report a mucoadhesive film composed of Ca-crosslinked carboxymethylated cellulose nanofibers and alginate, in which two drugs of dexamethasone (DXM) and dyclonine hydrochloride (DYC) are loaded for the treatment of oral ulcers. The wet films have a high Young's modulus of 7.1 ± 2.6 MPa and a large strain of 53.6 ± 9.8 % and adhere to tissue strongly, which allows them to resist the deformation caused by frequent oral movement. The films also have nice durability against water and excellent biocompatibility. Moreover, the drug release was controlled at different rates. The fast release of DYC facilitates the quick relief of pain, while the slow release of DXM benefits the long-term treatment of wounds. Finally, the animal experiment demonstrates the films displayed excellent therapeutic efficacy in healing oral ulcers.
复发性口腔溃疡是常见的口腔黏膜病变，严重降低患者的生活质量。市售的黏膜黏附膜由于口腔运动和复杂的湿润环境而容易破裂，从而降低药物利用率，甚至产生毒副作用。在此，我们报道了一种由钙交联羧甲基化纤维素纳米纤维和藻酸盐组成的黏膜黏附膜，其中负载了地塞米松（DXM）和盐酸达克罗宁（DYC）两种药物用于治疗口腔溃疡。湿膜具有7.1±2.6MPa的高杨氏模量和53.6±9.8%的大应变，并且与组织紧密黏附，这使其能够抵抗频繁口腔运动引起的变形。该膜还具有良好的耐水性和优异的生物相容性。此外，药物以不同速率释放。DYC的快速释放有助于迅速缓解疼痛，而DXM的缓慢释放有利于伤口的长期治疗。最后，动物实验表明该膜在治疗口腔溃疡方面显示出优异的治疗效果。
