• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

FADD调节脂肪组织炎症、脂肪生成和脂肪细胞存活。

FADD regulates adipose inflammation, adipogenesis, and adipocyte survival.

作者信息

Tang Jianlei, Ma Yue, Li Meilin, Liu Xiangpeng, Wang Yuting, Zhang Jie, Shu Hui, Liu Zhiwei, Zhang Chi, Fu Lei, Hu Ji, Zhang Yong, Jia Zhihao, Feng Yu

机构信息

Department of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Endocrinology Department of the Second People's Hospital of Lianyungang City, Lianyungang, China.

出版信息

Cell Death Discov. 2024 Jul 15;10(1):323. doi: 10.1038/s41420-024-02089-x.

DOI:10.1038/s41420-024-02089-x
PMID:39009585
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11250791/
Abstract

Adipose tissue, aside from adipocytes, comprises various abundant immune cells. The accumulation of low-grade chronic inflammation in adipose tissue serves as a primary cause and hallmark of insulin resistance. In this study, we investigate the physiological roles of FADD in adipose tissue inflammation, adipogenesis, and adipocyte survival. High levels of Fadd mRNA were observed in mitochondrial-rich organs, particularly brown adipose tissue. To explore its metabolic functions, we generated global Fadd knockout mice, resulting in embryonic lethality, while heterozygous knockout (Fadd+/-) mice did not show any significant changes in body weight or composition. However, Fadd+/- mice exhibited reduced respiratory exchange ratio (RER) and serum cholesterol levels, along with heightened global and adipose inflammatory responses. Furthermore, AT masses and expression levels of adipogenic and lipogenic genes were decreased in Fadd+/- mice. In cellular studies, Fadd inhibition disrupted adipogenic differentiation and suppressed the expression of adipogenic and lipogenic genes in cultured adipocytes. Additionally, Fadd overexpression caused adipocyte death in vitro with decreased RIPK1 and RIPK3 expression, while Fadd inhibition downregulated RIPK3 in iWAT in vivo. These findings collectively underscore the indispensable role of FADD in adipose inflammation, adipogenesis, and adipocyte survival.

摘要

除脂肪细胞外，脂肪组织还包含各种丰富的免疫细胞。脂肪组织中低度慢性炎症的积累是胰岛素抵抗的主要原因和标志。在本研究中，我们研究了FADD在脂肪组织炎症、脂肪生成和脂肪细胞存活中的生理作用。在富含线粒体的器官中，特别是棕色脂肪组织中观察到高水平的Fadd mRNA。为了探索其代谢功能，我们构建了全身性Fadd基因敲除小鼠，结果导致胚胎致死，而异ozygous基因敲除（Fadd+/-）小鼠的体重或组成没有任何显著变化。然而，Fadd+/-小鼠的呼吸交换率（RER）和血清胆固醇水平降低，同时全身和脂肪炎症反应增强。此外，Fadd+/-小鼠的脂肪组织质量以及脂肪生成和脂肪生成基因的表达水平降低。在细胞研究中，Fadd抑制破坏了脂肪生成分化，并抑制了培养的脂肪细胞中脂肪生成和脂肪生成基因的表达。此外，Fadd过表达在体外导致脂肪细胞死亡，同时RIPK1和RIPK3表达降低，而Fadd抑制在体内下调了iWAT中的RIPK3。这些发现共同强调了FADD在脂肪炎症、脂肪生成和脂肪细胞存活中不可或缺的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88d7/11250791/1fc396e82b19/41420_2024_2089_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88d7/11250791/9749fef18708/41420_2024_2089_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88d7/11250791/08353fef3877/41420_2024_2089_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88d7/11250791/a261fa3c258f/41420_2024_2089_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88d7/11250791/ffd84e2640f2/41420_2024_2089_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88d7/11250791/0fd60b958178/41420_2024_2089_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88d7/11250791/0beac2665214/41420_2024_2089_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88d7/11250791/988b302e41b3/41420_2024_2089_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88d7/11250791/1fc396e82b19/41420_2024_2089_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88d7/11250791/9749fef18708/41420_2024_2089_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88d7/11250791/08353fef3877/41420_2024_2089_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88d7/11250791/a261fa3c258f/41420_2024_2089_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88d7/11250791/ffd84e2640f2/41420_2024_2089_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88d7/11250791/0fd60b958178/41420_2024_2089_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88d7/11250791/0beac2665214/41420_2024_2089_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88d7/11250791/988b302e41b3/41420_2024_2089_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/88d7/11250791/1fc396e82b19/41420_2024_2089_Fig8_HTML.jpg

相似文献

1
FADD regulates adipose inflammation, adipogenesis, and adipocyte survival.FADD调节脂肪组织炎症、脂肪生成和脂肪细胞存活。
Cell Death Discov. 2024 Jul 15;10(1):323. doi: 10.1038/s41420-024-02089-x.
2
Type VI collagen and its cleavage product, endotrophin, cooperatively regulate the adipogenic and lipolytic capacity of adipocytes.类型 VI 胶原蛋白及其裂解产物内脂素协同调节脂肪细胞的成脂和脂解能力。
Metabolism. 2021 Jan;114:154430. doi: 10.1016/j.metabol.2020.154430. Epub 2020 Nov 12.
3
MicroRNA-10a-5p regulates macrophage polarization and promotes therapeutic adipose tissue remodeling.miR-10a-5p 调控巨噬细胞极化并促进治疗性脂肪组织重塑。
Mol Metab. 2019 Nov;29:86-98. doi: 10.1016/j.molmet.2019.08.015. Epub 2019 Aug 27.
4
Adiponectin stimulates Sca1CD34-adipocyte precursor cells associated with hyperplastic expansion and beiging of brown and white adipose tissue.脂联素刺激与棕色和白色脂肪组织的增生性扩张及米色化相关的Sca1CD34脂肪细胞前体细胞。
Metabolism. 2024 Feb;151:155716. doi: 10.1016/j.metabol.2023.155716. Epub 2023 Nov 2.
5
Wntless regulates lipogenic gene expression in adipocytes and protects against diet-induced metabolic dysfunction.Wntless 调节脂肪细胞中的脂肪生成基因表达，并防止饮食引起的代谢功能障碍。
Mol Metab. 2020 Sep;39:100992. doi: 10.1016/j.molmet.2020.100992. Epub 2020 Apr 20.
6
Wnt/β-catenin signaling regulates adipose tissue lipogenesis and adipocyte-specific loss is rigorously defended by neighboring stromal-vascular cells.Wnt/β-catenin 信号通路调控脂肪组织的脂生成，相邻的基质血管细胞严格地保护脂肪细胞特异性缺失。
Mol Metab. 2020 Dec;42:101078. doi: 10.1016/j.molmet.2020.101078. Epub 2020 Sep 9.
7
Quercetin attenuates adipose hypertrophy, in part through activation of adipogenesis in rats fed a high-fat diet.槲皮素通过激活高脂肪饮食喂养的大鼠的脂肪生成，部分减轻脂肪肥大。
J Nutr Biochem. 2020 May;79:108352. doi: 10.1016/j.jnutbio.2020.108352. Epub 2020 Feb 4.
8
Adipocyte-specific Hypoxia-inducible gene 2 promotes fat deposition and diet-induced insulin resistance.脂肪细胞特异性缺氧诱导因子 2 促进脂肪沉积和饮食诱导的胰岛素抵抗。
Mol Metab. 2016 Sep 28;5(12):1149-1161. doi: 10.1016/j.molmet.2016.09.009. eCollection 2016 Dec.
9
Deleted in breast cancer 1 plays a functional role in adipocyte differentiation.抑癌基因 DBC1 在脂肪细胞分化中发挥功能作用。
Am J Physiol Endocrinol Metab. 2015 Apr 1;308(7):E554-61. doi: 10.1152/ajpendo.00286.2014. Epub 2015 Feb 3.
10
Requirement of Cavin-2 for the expression and stability of IRβ in adequate adipocyte differentiation.Cavin-2 对 IRβ 在充分的脂肪细胞分化中的表达和稳定性的需求。
Mol Metab. 2022 Jan;55:101416. doi: 10.1016/j.molmet.2021.101416. Epub 2021 Dec 9.

本文引用的文献

1
Cell death and inflammation during obesity: "Know my methods, WAT(son)".肥胖症发生过程中的细胞死亡与炎症：“了解我的方法，脂肪组织（儿子）”。
Cell Death Differ. 2023 Feb;30(2):279-292. doi: 10.1038/s41418-022-01062-4. Epub 2022 Sep 29.
2
ACSS3 in brown fat drives propionate catabolism and its deficiency leads to autophagy and systemic metabolic dysfunction.ACSS3 在棕色脂肪中驱动丙酸盐分解代谢，其缺乏导致自噬和全身代谢功能障碍。
Clin Transl Med. 2022 Feb;12(2):e665. doi: 10.1002/ctm2.665.
3
RIPK1 Coordinates Bone Marrow Mesenchymal Stem Cell Survival by Maintaining Mitochondrial Homeostasis via p53.
RIPK1通过p53维持线粒体稳态来协调骨髓间充质干细胞的存活。
Stem Cells Int. 2021 Nov 19;2021:5540149. doi: 10.1155/2021/5540149. eCollection 2021.
4
Adiponectin, Leptin and Cardiovascular Disorders.脂联素、瘦素与心血管疾病
Circ Res. 2021 Jan 8;128(1):136-149. doi: 10.1161/CIRCRESAHA.120.314458. Epub 2021 Jan 7.
5
FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells.FADD 和 Caspase-8 通过调控 MLKL 和 GSDMD 介导体肠上皮细胞死亡来调节肠道稳态和炎症。
Immunity. 2020 Jun 16;52(6):978-993.e6. doi: 10.1016/j.immuni.2020.04.002. Epub 2020 May 1.
6
Adipose Tissue-Liver Cross Talk in the Control of Whole-Body Metabolism: Implications in Nonalcoholic Fatty Liver Disease.脂肪组织-肝脏对话在全身代谢调控中的作用：非酒精性脂肪性肝病的启示。
Gastroenterology. 2020 May;158(7):1899-1912. doi: 10.1053/j.gastro.2019.12.054. Epub 2020 Feb 13.
7
Tissue Immune Cells Fuel Obesity-Associated Inflammation in Adipose Tissue and Beyond.组织免疫细胞为脂肪组织及其他组织的肥胖相关性炎症提供燃料。
Front Immunol. 2019 Jul 17;10:1587. doi: 10.3389/fimmu.2019.01587. eCollection 2019.
8
Adipose Tissue-Resident Immune Cells in Obesity and Type 2 Diabetes.肥胖症和 2 型糖尿病中的脂肪组织驻留免疫细胞。
Front Immunol. 2019 May 22;10:1173. doi: 10.3389/fimmu.2019.01173. eCollection 2019.
9
FADD at the Crossroads between Cancer and Inflammation.FADD 在癌症与炎症的十字路口。
Trends Immunol. 2018 Dec;39(12):1036-1053. doi: 10.1016/j.it.2018.10.005. Epub 2018 Nov 3.
10
Properties and functions of adipose tissue macrophages in obesity.肥胖症中脂肪组织巨噬细胞的特性和功能。
Immunology. 2018 Dec;155(4):407-417. doi: 10.1111/imm.13002. Epub 2018 Oct 19.