Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Korea.
Department of Ophthalmology, Chungnam National University Hospital, Daejeon, Korea.
Sci Rep. 2024 Jul 15;14(1):16286. doi: 10.1038/s41598-024-66559-z.
Nationwide incidence and risk factors for incisional glaucoma surgery post-infantile cataract (IC) surgery in children remain poorly understood. We conducted a population-based cohort study using the Korean national health claims database to identify IC patients diagnosed before age 1 who had IC surgery among all Korean born between 2008 and 2018 (n = 9,593,003). We estimated the annual occurrence of undergoing incisional glaucoma surgery following IC surgery in the general population aged 0-10. The risk factors for incisional surgery including systemic comorbidities and ophthalmic anomalies were analyzed by multivariable logistic regression. Of 650 patients who had undergone IC surgery with a mean (standard deviation [SD]) follow-up period of 6.2 (3.2) years, 92 (14.2%) were diagnosed with glaucoma following infantile cataract surgery (GFICS). Among them, 21 patients (22.8%) underwent incisional glaucoma surgery after a mean (SD) follow-up duration of 5.4 (2.8) years from the diagnosis of GFICS. Median (InterQuartile Range) age at incisional surgery was 4 (2,6) years old. Twenty of 21 patients (95.2%) underwent incisional glaucoma surgery within 3 years of diagnosis of GFICS. No factors, except younger age at glaucoma diagnosis (P = 0.03), were associated with undergoing incisional surgery. These findings can better understand the epidemiologic features and clinical courses of GFICS.
全国范围内，儿童期白内障（IC）术后切口性青光眼手术的发病率和危险因素仍知之甚少。我们使用韩国国家健康保险索赔数据库进行了一项基于人群的队列研究，以确定在 2008 年至 2018 年期间出生的所有韩国人中，1 岁前被诊断为 IC 的患者（n=9,593,003）。我们估计了 0-10 岁普通人群中接受 IC 手术后行切口性青光眼手术的年发生率。通过多变量逻辑回归分析了切口手术的危险因素，包括全身合并症和眼部异常。在 650 名接受 IC 手术的患者中，平均（标准差[SD]）随访期为 6.2（3.2）年，92 名（14.2%）在婴儿白内障手术后被诊断为青光眼（GFICS）。在他们中，21 名患者（22.8%）在 GFICS 诊断后平均（SD）随访 5.4（2.8）年后接受了切口性青光眼手术。中位（四分位距）手术年龄为 4（2，6）岁。21 名患者中有 20 名（95.2%）在 GFICS 诊断后 3 年内接受了切口性青光眼手术。除了青光眼诊断年龄较小（P=0.03）外，没有其他因素与接受切口手术相关。这些发现可以更好地了解 GFICS 的流行病学特征和临床过程。
