新生儿面部葡萄酒色斑表型与青光眼风险的相关性。

Facial Port-Wine Stain Phenotypes Associated with Glaucoma Risk in Neonates.

机构信息

Department of Ophthalmology, Jeju National University Hospital, Jeju-si, Korea; Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea; Childhood Glaucoma Research Group, Seoul National University (SNU), Seoul, Korea.

Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea; Childhood Glaucoma Research Group, Seoul National University (SNU), Seoul, Korea; Department of Ophthalmology, Chungnam National University Sejong Hospital, Sejong, Korea.

出版信息

Am J Ophthalmol. 2020 Dec;220:183-190. doi: 10.1016/j.ajo.2020.08.003. Epub 2020 Aug 12.

DOI:10.1016/j.ajo.2020.08.003

PMID:32795435

Abstract

PURPOSE

To determine if the size and location of facial port-wine stains (PWS) can predict glaucoma risk in neonates.

DESIGN

Retrospective cohort study.

METHODS

Children with facial PWS who had undergone ophthalmologic examination within 4 weeks of their birth were included. Clinical information, including facial photographs, intraocular pressure, corneal diameter, optic disc cup-to-disc ratio, and Sturge-Weber syndrome (SWS) diagnoses were collected. Based on facial photographs, PWS distribution, eyelid involvement, and PWS scores according to degree of involvement in each embryonic facial vasculature distribution (segment [S]1, S2 and S3) were evaluated.

RESULTS

Among the 34 patients, 7 (21%) had bilateral PWS lesions. Eighteen (53%) had diagnoses of glaucoma. The proportion of eyes showing PWS involving both S1 and S2 was the highest (n = 15, 37%), and the frequency of glaucoma diagnosis (n = 9, 60%) was also the greatest. In eyelid involvement analysis, among the 7 eyes with only lower-eyelid lesions, 5 (83%) had glaucoma. Among the 11 eyes with only upper-eyelid lesions, however, 2 (18%) had diagnoses of glaucoma. A logistic regression model showed that the significant factors associated with glaucoma risk were greater PWS scores in S2 (odds ratio [OR]: 3.604; 95% confidence interval: 1.078-12.050; P = .037) or lower-eyelid involvement (OR: 12.816; 95% CI: 1.698-96.744; P = .013).

CONCLUSIONS

Among the newborns with facial PWS, 1) a greater extent of birthmarks involving the S2 area, and 2) lesions including the lower eyelid were associated with higher risk of glaucoma development within the neonatal period.

摘要

目的

确定面部葡萄酒色斑（PWS）的大小和位置是否可以预测新生儿的青光眼风险。

设计

回顾性队列研究。

方法

纳入了出生后 4 周内接受过眼科检查的面部 PWS 患儿。收集了临床信息，包括面部照片、眼压、角膜直径、视盘杯盘比和 Sturge-Weber 综合征（SWS）诊断。根据面部照片评估 PWS 分布、眼睑受累情况以及根据每个胚胎面部血管分布（段[S]1、S2 和 S3）受累程度的 PWS 评分。

结果

在 34 名患者中，有 7 名（21%）患有双侧 PWS 病变。18 名（53%）患有青光眼诊断。累及 S1 和 S2 的 PWS 眼的比例最高（n=15，37%），青光眼诊断的频率（n=9，60%）也最高。在眼睑受累分析中，在仅累及下眼睑的 7 只眼中，有 5 只（83%）患有青光眼。然而，在仅累及上眼睑的 11 只眼中，有 2 只（18%）患有青光眼诊断。逻辑回归模型显示，与青光眼风险相关的显著因素是 S2 中更大的 PWS 评分（比值比[OR]：3.604；95%置信区间：1.078-12.050；P=0.037）或下眼睑受累（OR：12.816；95%CI：1.698-96.744；P=0.013）。