Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China.
Department of Cardiac Surgery, Chest Hospital, Tianjin University, Tianjin, China.
J Cardiovasc Transl Res. 2024 Oct;17(5):1193-1204. doi: 10.1007/s12265-024-10524-8. Epub 2024 Jul 15.
Postoperative Atrial Fibrillation (POAF) frequently follows Coronary Artery Bypass Grafting (CABG) surgery. This prospective study investigates genes linked to POAF in CABG patients, aiming to create a predictive model. Employing differential gene and methylation analyses, the study identified four genes (WARS2, CKAP2, CHI3L1, HSD17B6) associated with POAF. Preoperative plasma samples and clinical data were collected from 139 CABG patients, categorized into POAF (+) (43) and POAF (-) (96). Real-time quantitative PCR assessed gene expression, and a predictive model using the LASSO method demonstrated robust performance, with AUC values of 0.8895 in the training set and 0.7840 in the test set. This pioneering study integrates genomics and clinical data, suggesting WARS2, CKAP2, and CHI3L1 as potential indicators for POAF prediction.
术后心房颤动（POAF）常常发生在冠状动脉旁路移植术（CABG）之后。本前瞻性研究调查了与 CABG 患者 POAF 相关的基因，旨在建立一个预测模型。通过差异基因和甲基化分析，研究发现了四个与 POAF 相关的基因（WARS2、CKAP2、CHI3L1、HSD17B6）。从 139 名 CABG 患者中采集了术前血浆样本和临床数据，分为 POAF（+）（43 例）和 POAF（-）（96 例）。实时定量 PCR 评估了基因表达，使用 LASSO 方法建立的预测模型在训练集和测试集的 AUC 值分别为 0.8895 和 0.7840，表现出稳健的性能。这项开创性的研究整合了基因组学和临床数据，提示 WARS2、CKAP2 和 CHI3L1 可能是 POAF 预测的指标。
