Department of Pediatrics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, Zhejiang, 317000, China.
Evidence-Based Medicine Center, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, 150 Ximen Street, Linhai, Zhejiang, 317000, China.
BMC Pediatr. 2024 Jul 15;24(1):451. doi: 10.1186/s12887-024-04932-7.
To investigate the relationship between cord blood levels of Angiopoietin-1 (Ang-1) and S-endoglin (sCD105) and bronchopulmonary dysplasia (BPD) in preterm infants.
Sixty-one preterm infants admitted to the neonatal intensive care unit of the study hospital between July 2021 and September 2022 were included. Cord blood was collected after the birth of premature infants. Ang-1 and sCD105 levels were quantified using the vascular endothelial growth factor enzyme-linked immunosorbent assay. Preterm infants were divided into BPD and non-BPD groups, and differences in Ang-1 and sCD105 levels between the two groups were compared. A binary logistic model was used to assess the association between low and high levels Ang-1 and BPD in preterm infants.
In the study, there were 20 preterm infants with BPD (32.8%) and 41 preterm infants with non-BPD (67.2%). Ang-1 concentration levels were lower in the BPD group than in the non-BPD group (7105.43 (5617.01-8523.00) pg/ml vs. 10488.03 (7946.19-15962.77) pg/ml, P = 0.027). However, the sCD105 concentration levels were not significantly different between the BPD and non-BPD groups (P = 0.246). A median Ang-1 concentration of 8800.40 pg/ml was calculated. Logistic regression analysis showed that after adjusting for gestational age, birth weight, and maternal prenatal steroid hormone application, the odds ratio (OR) was 8.577 for the risk of BPD in preterm infants with Ang-1 concentrations of ≤ 8800.40 pg/ml compared to those with Ang-1 concentrations of > 8800.40 pg/ml (OR: 8.577, 95% confidence interval: 1.265-58.155, P = 0.028).
Our study indicated that Ang-1 levels in the cord blood of preterm infants may be associated the risk of BPD. In the future, we will continue to conduct study with large samples.
研究目的在于探讨早产儿脐带血中血管生成素-1（Ang-1）和 S-内皮糖蛋白（sCD105）水平与支气管肺发育不良（BPD）之间的关系。
选取 2021 年 7 月至 2022 年 9 月在我院新生儿重症监护病房住院的 61 例早产儿，采集早产儿出生后的脐带血，采用血管内皮生长因子酶联免疫吸附试验定量检测 Ang-1 和 sCD105 水平。将早产儿分为 BPD 组和非 BPD 组，比较两组间 Ang-1 和 sCD105 水平的差异。采用二项逻辑回归模型评估早产儿中 Ang-1 水平的低值与 BPD 的关系。
本研究中，BPD 患儿 20 例（32.8%），非 BPD 患儿 41 例（67.2%）。BPD 组 Ang-1 浓度低于非 BPD 组（7105.43（5617.01-8523.00）pg/ml 比 10488.03（7946.19-15962.77）pg/ml，P=0.027）。然而，BPD 组和非 BPD 组 sCD105 浓度无显著差异（P=0.246）。计算中位数 Ang-1 浓度为 8800.40 pg/ml。Logistic 回归分析显示，在校正胎龄、出生体重和母亲产前应用类固醇激素后，Ang-1 浓度≤8800.40 pg/ml 的早产儿患 BPD 的风险比（OR）为 8.577（95%置信区间：1.265-58.155，P=0.028）。
本研究表明，早产儿脐带血中 Ang-1 水平可能与 BPD 的发病风险相关。未来，我们将继续进行大样本研究。
Zotero 插件