Kim Do-Hyun, Shin Seung Han, Kim Ee-Kyung, Kim Han-Suk
Department of Pediatrics, Dongguk University Ilsan Hospital, Goyang, Republic of Korea.
Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea.
Pregnancy Hypertens. 2018 Jul;13:148-153. doi: 10.1016/j.preghy.2018.06.002. Epub 2018 Jun 9.
To investigate whether the levels of angiogenic factors in cord blood are associated with the development of bronchopulmonary dysplasia (BPD) in preterm infants with maternal preeclampsia.
This retrospective cohort study included 199 singleton infants (gestational age < 32 weeks), including the preeclampsia group (59 infants) with severe/moderate BPD (24 infants) or no/mild BPD (35 infants) and the no preeclampsia group (140 infants).
The levels of soluble fms-like tyrosine kinase-1 (sFlt-1), soluble endoglin, and placental growth factor (PlGF) in cord blood were measured and compared among the study groups.
The soluble endoglin level and the ratio of (sFlt-1 + soluble endoglin) to PlGF were significantly higher in the preeclampsia group than in the no preeclampsia group (P < .05). Among preterm infants with maternal preeclampsia, both of these parameters were also significantly higher in the severe/moderate BPD group than the no/mild BPD group (P < .05). Receiver operator curve analysis revealed that increased cord blood soluble endoglin was predictive of severe or moderate BPD in preterm infants with maternal preeclampsia (area under the curve 0.73). Gestational age (adjusted odds ratio [OR] 0.25; P < .001) and high soluble endoglin level in cord blood (>3420 pg/mL) (adjusted OR 11.9; P = .006) were significant risk factors for the development of severe or moderate BPD in the preeclampsia group according to multivariate logistic regression analysis.
Increased cord blood soluble endoglin is associated with the development of severe or moderate BPD in preterm infants with maternal preeclampsia.
探讨患有子痫前期孕妇的早产婴儿脐带血中血管生成因子水平与支气管肺发育不良（BPD）发生之间的关联。
这项回顾性队列研究纳入了199名单胎婴儿（胎龄<32周），包括子痫前期组（59名婴儿），其中有重度/中度BPD的婴儿（24名）或无/轻度BPD的婴儿（35名），以及非子痫前期组（140名婴儿）。
测量并比较各研究组脐带血中可溶性fms样酪氨酸激酶-1（sFlt-1）、可溶性内皮糖蛋白和胎盘生长因子（PlGF）的水平。
子痫前期组的可溶性内皮糖蛋白水平以及（sFlt-1 + 可溶性内皮糖蛋白）与PlGF的比值显著高于非子痫前期组（P<0.05）。在患有子痫前期孕妇的早产婴儿中，这两个参数在重度/中度BPD组也显著高于无/轻度BPD组（P<0.05）。受试者工作特征曲线分析显示，脐带血中可溶性内皮糖蛋白升高可预测患有子痫前期孕妇的早产婴儿发生重度或中度BPD（曲线下面积为0.73）。根据多因素逻辑回归分析，胎龄（调整优势比[OR]为0.25；P<0.001）和脐带血中可溶性内皮糖蛋白水平高（>3420 pg/mL）（调整OR为11.9；P = 0.006）是子痫前期组发生重度或中度BPD的显著危险因素。
脐带血中可溶性内皮糖蛋白升高与患有子痫前期孕妇的早产婴儿发生重度或中度BPD有关。
