脐血浆血管生成素-1 和内皮抑素水平预测早产儿支气管肺发育不良的发生。
Angiopoietin-1 and endostatin levels in cord plasma predict the development of bronchopulmonary dysplasia in preterm infants.
机构信息
Department of Pediatrics, College of Medicine, King Khalid University, Abha, Saudi Arabia.
出版信息
J Trop Pediatr. 2011 Oct;57(5):385-8. doi: 10.1093/tropej/fmq112. Epub 2010 Dec 2.
OBJECTIVE
To determine whether angiopoietin-1 and endostatin levels in the cord blood could predict the subsequent development of bronchopulmonary dysplasia (BPD) in preterm infants.
PATIENTS AND METHODS
A total of 102 preterm (gestational age ≤ 32 weeks) infants (28 infants developed BPD and 74 had no BPD) were enrolled in the study. Cord plasma levels of angiopoietin-1 and endostatin were measured by enzyme-linked immunosorbent assay.
RESULTS
Preterm infants who subsequently developed BPD had significantly lower cord plasma levels of angiopoietin-1 than those who did not (p < 0.001). Our results showed that cord plasma levels of endostatin were significantly higher in infants with BPD than in those without (p < 0.001). In infants with BPD, angiopoietin-1 levels in cord plasma correlated negatively with endostatin (r = -0.48; p = 0.008).
CONCLUSION
In preterm infants, low-angiopoietin-1 and high-endostatin levels in cord plasma at birth predict the subsequent development of BPD.
目的
探讨脐血血管生成素-1（angiopoietin-1，Ang-1）和内皮抑素（endostatin）水平能否预测早产儿支气管肺发育不良（bronchopulmonary dysplasia，BPD）的发生。
方法
选择胎龄≤32 周的早产儿 102 例，其中 28 例发生 BPD，74 例未发生 BPD。采用酶联免疫吸附法检测脐血 Ang-1 和内皮抑素水平。
结果
发生 BPD 的早产儿脐血 Ang-1 水平明显低于未发生 BPD 的早产儿（p<0.001）；BPD 组脐血内皮抑素水平明显高于未发生 BPD 的早产儿（p<0.001）；BPD 组脐血 Ang-1 水平与内皮抑素水平呈负相关（r=-0.48，p=0.008）。
结论
出生时脐血 Ang-1 水平降低和内皮抑素水平升高可能预测早产儿 BPD 的发生。
Zotero 插件