Institute for Biometrics and Epidemiology, German Diabetes Centre, Leibniz Centre for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
German Centre for Diabetes Research (DZD), Partner Düsseldorf, Neuherberg, Germany.
Diabetes Obes Metab. 2024 Oct;26(10):4281-4292. doi: 10.1111/dom.15772. Epub 2024 Jul 15.
To investigate the associations of the Dietary Approaches to Stop Hypertension (DASH) score with subcutaneous (SAT) and visceral (VAT) adipose tissue volume and hepatic lipid content (HLC) in people with diabetes and to examine whether changes in the DASH diet were associated with changes in these outcomes.
In total, 335 participants with recent-onset type 1 diabetes (T1D) and type 2 diabetes (T2D) from the German Diabetes Study were included in the cross-sectional analysis, and 111 participants in the analysis of changes during the 5-year follow-up. Associations between the DASH score and VAT, SAT and HLC and their changes were investigated using multivariable linear regression models by diabetes type. The proportion mediated by changes in potential mediators was determined using mediation analysis.
A higher baseline DASH score was associated with lower HLC, especially in people with T2D (per 5 points: -1.5% [-2.7%; -0.3%]). Over 5 years, a 5-point increase in the DASH score was associated with decreased VAT in people with T2D (-514 [-800; -228] cm). Similar, but imprecise, associations were observed for VAT changes in people with T1D (-403 [-861; 55] cm) and for HLC in people with T2D (-1.3% [-2.8%; 0.3%]). Body mass index and waist circumference changes explained 8%-48% of the associations between DASH and VAT changes in both groups. In people with T2D, adipose tissue insulin resistance index (Adipo-IR) changes explained 47% of the association between DASH and HLC changes.
A shift to a DASH-like diet was associated with favourable VAT and HLC changes, which were partly explained by changes in anthropometric measures and Adipo-IR.
探讨膳食方法阻止高血压（DASH）评分与糖尿病患者皮下（SAT）和内脏（VAT）脂肪组织体积和肝脂含量（HLC）的相关性，并研究 DASH 饮食的变化是否与这些结果的变化相关。
共有 335 名新发 1 型糖尿病（T1D）和 2 型糖尿病（T2D）患者参与了横断面分析，111 名患者参与了 5 年随访期间的变化分析。采用多元线性回归模型，按糖尿病类型分析 DASH 评分与 VAT、SAT 和 HLC 及其变化之间的关系。采用中介分析确定潜在中介因素变化的介导比例。
基线 DASH 评分较高与 HLC 水平较低相关，尤其是在 T2D 患者中（每增加 5 分：-1.5%[-2.7%；-0.3%]）。在 5 年内，DASH 评分增加 5 分与 T2D 患者的 VAT 减少相关（-514[-800；-228]cm）。T1D 患者的 VAT 变化（-403[-861；55]cm）和 T2D 患者的 HLC 变化（-1.3%[-2.8%；0.3%]）也观察到类似但不精确的相关性。在两组患者中，DASH 与 VAT 变化之间的相关性，体重指数和腰围变化解释了 8%-48%。在 T2D 患者中，脂肪组织胰岛素抵抗指数（Adipo-IR）变化解释了 DASH 与 HLC 变化之间相关性的 47%。
向 DASH 饮食的转变与有利的 VAT 和 HLC 变化相关，这些变化部分由人体测量指标和 Adipo-IR 的变化所解释。
