Liu Lin, Feng Jitao, Zhang Gong, Yuan Xiaodan, Li Fan, Yang Tingting, Hao Shujie, Huang Dejian, Hsue Cunyi, Lou Qinging
a Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine , Nanjing , Jiangsu Province , PR China.
b Seven OAKS General Hospital , Winnipeg , Canada.
Curr Med Res Opin. 2018 Jan;34(1):123-129. doi: 10.1080/03007995.2017.1364226. Epub 2017 Aug 31.
To investigate the value of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) in a cohort of a community's residents who were diagnosed as pre-diabetes, and to evaluate the association of VAT and SAT with insulin resistance.
This study was based on cross-sectional analysis of data from 107 adults. VAT and SAT were assessed by computed tomography. Insulin resistance was defined by homeostasis model assessment of insulin resistance >2.69. The relationship of VAT and SAT with insulin resistance were examined by linear regression. Logistic regression was used to analyze the association of VAT and SAT with insulin resistance.
A total of 87 subjects had VAT ≥100 cm. Thirty-six out of 107 (33.6%) subjects were detected to have insulin resistance, 71 were normal (66.4%), and all had insulin resistance with VAT ≥100 cm. VAT (r = 0.378, p < .001) and SAT (r = 0.357, p < .001) were significantly and positively correlated with insulin resistance. In multiple regression analysis when VAT and SAT were simultaneously included after adjustment for age, gender, BMI, and WC, the association between VAT and insulin resistance was still maintained (p = .003), but that of SAT was lost.
Pre-diabetic subjects with insulin resistance had elevated levels of VAT. VAT was more strongly associated with insulin resistance than SAT in Chinese subjects with pre-diabetes.
研究在一组被诊断为糖尿病前期的社区居民中，内脏脂肪组织（VAT）和皮下脂肪组织（SAT）的价值，并评估VAT和SAT与胰岛素抵抗的关联。
本研究基于对107名成年人数据的横断面分析。通过计算机断层扫描评估VAT和SAT。胰岛素抵抗通过稳态模型评估胰岛素抵抗>2.69来定义。采用线性回归检验VAT和SAT与胰岛素抵抗的关系。使用逻辑回归分析VAT和SAT与胰岛素抵抗的关联。
共有87名受试者的VAT≥100 cm。107名受试者中有36名（33.6%）被检测出有胰岛素抵抗，71名正常（66.4%），且所有有胰岛素抵抗的受试者VAT均≥100 cm。VAT（r = 0.378，p <.001）和SAT（r = 0.357，p <.001）与胰岛素抵抗显著正相关。在多因素回归分析中，在调整年龄、性别、BMI和腰围后同时纳入VAT和SAT，VAT与胰岛素抵抗之间的关联仍然存在（p = 0.003），但SAT与胰岛素抵抗的关联消失。
有胰岛素抵抗的糖尿病前期受试者的VAT水平升高。在中国糖尿病前期受试者中，VAT与胰岛素抵抗的关联比SAT更强。
