Jorgensen J H
Prog Clin Biol Res. 1985;189:387-403.
The Limulus amebocyte lysate (LAL) assay has realized numerous clinical applications, including rapid diagnosis of significant Gram negative bacteriuria and gonorrhea. Several published studies have demonstrated that the LAL test detects significant Gram negative bacteriuria with greater than 90% accuracy and that the predictive value of a negative test (97%) is similar to that of other currently available screening methods for bacteriuria. The test has also succeeded when used for presumptive diagnosis of gonorrhea in men, although it has not been shown to be superior to Gram stain examination of urethral exudate. The LAL test appears to offer excellent sensitivity for examination of cervical secretions from women being screened for gonorrhea, although the specificity of the test appears low, especially when a low-risk population is being examined.
鲎试剂检测法已在众多临床应用中得到实现，包括对严重革兰氏阴性菌尿症和淋病的快速诊断。多项已发表的研究表明，鲎试剂检测法检测严重革兰氏阴性菌尿症的准确率高于90%，且阴性检测结果的预测值（97%）与目前其他可用的菌尿症筛查方法相似。该检测法用于男性淋病的初步诊断时也取得了成功，不过尚未证明其优于尿道分泌物的革兰氏染色检查。鲎试剂检测法在筛查淋病的女性宫颈分泌物检查中似乎具有出色灵敏度，尽管该检测法的特异性似乎较低，尤其是在检测低风险人群时。
