内毒素、血液成分与血管壁之间的相互作用。
Interaction of endotoxins, blood elements and the vessel wall.
作者信息
Osterud B
出版信息
Prog Clin Biol Res. 1985;189:67-79.
Endotoxins are potent activators of the complement system. Formed activated complement factors, in turn, are capable of inducing metabolite production that may be essential in the killing of parasites. However, the products formed may also induce severe damage and cause great pathological changes that can be fatal for the individual infected. In the present review article the interaction of endotoxin with monocytes, granulocytes and endothelial cells, as well as the central role of complement activation will be discussed. Also a method is provided for the detection of cell activation in Neisseria meningitidis infection.
内毒素是补体系统的强效激活剂。反过来，形成的活化补体因子能够诱导代谢产物的产生，这在杀死寄生虫方面可能至关重要。然而，形成的产物也可能导致严重损伤并引起巨大的病理变化，这对受感染个体可能是致命的。在本综述文章中，将讨论内毒素与单核细胞、粒细胞和内皮细胞的相互作用，以及补体激活的核心作用。此外，还提供了一种检测脑膜炎奈瑟菌感染中细胞活化的方法。
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