Gaynor E, Bouvier C, Spaet T H
Science. 1970 Nov 27;170(3961):986-8. doi: 10.1126/science.170.3961.986.
Evidence of vascular injury was found in rabbits after a single small dose of endotoxin from Escherichia coli. Eighty percent of the treated animals developed circulating endothelial cells, leukopenia, and thrombocytopenia, and 50 percent had aortic endothelial lesions as determined by electron microscopy. Prior anticoagulation with heparin did not prevent this response. No control animals showed these abnormalities.
在给兔子单次注射小剂量大肠杆菌内毒素后，发现了血管损伤的证据。80%的受试动物出现循环内皮细胞、白细胞减少和血小板减少，通过电子显微镜检查确定，50%的动物有主动脉内皮损伤。预先用肝素抗凝并不能阻止这种反应。没有对照动物出现这些异常情况。
