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Time-varying covariates, overadjustment bias and mediation in pharmacokinetic/pharmacodynamic modeling.

作者信息

Goulooze Sebastiaan Camiel, Snelder Nelleke

机构信息

LAP&P Consultants BV, Leiden, The Netherlands.

出版信息

CPT Pharmacometrics Syst Pharmacol. 2024 Aug;13(8):1285-1288. doi: 10.1002/psp4.13200. Epub 2024 Jul 16.

DOI:10.1002/psp4.13200
PMID:39010750
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11330179/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0988/11330179/0ccd84d0187a/PSP4-13-1285-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0988/11330179/c0361c2dba30/PSP4-13-1285-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0988/11330179/0ccd84d0187a/PSP4-13-1285-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0988/11330179/c0361c2dba30/PSP4-13-1285-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0988/11330179/0ccd84d0187a/PSP4-13-1285-g002.jpg

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Pharmacokinetics and pharmacodynamics of finerenone in patients with chronic kidney disease and type 2 diabetes: Insights based on FIGARO-DKD and FIDELIO-DKD.非奈利酮在慢性肾脏病合并 2 型糖尿病患者中的药代动力学和药效学:基于 FIGARO-DKD 和 FIDELIO-DKD 的研究结果。
Diabetes Obes Metab. 2024 Mar;26(3):924-936. doi: 10.1111/dom.15387. Epub 2023 Nov 30.
3
Innovations in Pediatric Therapeutics Development: Principles for the Use of Bridging Biomarkers in Pediatric Extrapolation.
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Ther Innov Regul Sci. 2023 Jan;57(1):109-120. doi: 10.1007/s43441-022-00445-6. Epub 2022 Sep 3.
4
Mediation analysis methods used in observational research: a scoping review and recommendations.观察性研究中中介分析方法的应用:范围综述及建议。
BMC Med Res Methodol. 2021 Oct 25;21(1):226. doi: 10.1186/s12874-021-01426-3.
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Revisiting Overadjustment Bias.重新审视过度调整偏差。
Epidemiology. 2021 Sep 1;32(5):e22-e23. doi: 10.1097/EDE.0000000000001377.
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Mediation Analysis: A Practitioner's Guide.中介分析:实践者指南。
Annu Rev Public Health. 2016;37:17-32. doi: 10.1146/annurev-publhealth-032315-021402. Epub 2015 Nov 30.
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Mediation analysis in epidemiology: methods, interpretation and bias.流行病学中的中介分析:方法、解释和偏倚。
Int J Epidemiol. 2013 Oct;42(5):1511-9. doi: 10.1093/ije/dyt127. Epub 2013 Sep 9.
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