Department of Nuclear Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing, 211106, China.
Joint International Research Laboratory on Advanced Particle Therapy, Nanjing University of Aeronautics and Astronautics, Nanjing, 211100, China.
Radiat Prot Dosimetry. 2024 Sep 10;200(14):1319-1328. doi: 10.1093/rpd/ncae158.
This study introduces the MKM_B model, an approach derived from the MKM model, designed to evaluate the biological effectiveness of Boron Neutron Capture Therapy (BNCT) in the face of challenges from varying microscopic boron distributions. The model introduces a boron compensation factor, allowing for the assessment of compound Biological Effectiveness (CBE) values for different boron distributions. Utilizing the TOPAS simulation platform, the lineal energy spectrum of particles in BNCT was simulated, and the sensitivity of the MKM_B model to parameter variations and the influence of cell size on the model were thoroughly investigated. The CBE values for 10B-boronphenylalanine (BPA) and 10B-sodium (BSH) were determined to be 3.70 and 1.75, respectively. These calculations were based on using the nucleus radius of 2.5 μm and the cell radius of 5 μm while considering a 50% surviving fraction. It was observed that as cell size decreased, the CBE values for both BPA and BSH increased. Additionally, the model parameter rd was identified as having the most significant impact on CBE, with other parameters showing moderate effects. The development of the MKM_B model enables the accurate prediction of CBE under different boron distributions in BNCT. This model offers a promising approach to optimize treatment planning by providing increased accuracy in biological effectiveness.
本研究介绍了 MKM_B 模型，该模型源自 MKM 模型，旨在评估硼中子俘获治疗（BNCT）在面对不同微观硼分布挑战时的生物学有效性。该模型引入了硼补偿因子，允许评估不同硼分布的复合生物学有效性（CBE）值。利用 TOPAS 模拟平台，模拟了 BNCT 中粒子的线性能量谱，并彻底研究了 MKM_B 模型对参数变化的敏感性以及细胞大小对模型的影响。确定 10B-硼苯丙氨酸（BPA）和 10B-硼酸钠（BSH）的 CBE 值分别为 3.70 和 1.75。这些计算是基于使用 2.5μm 的核半径和 5μm 的细胞半径，同时考虑 50%的存活分数。结果表明，随着细胞尺寸的减小，BPA 和 BSH 的 CBE 值均增加。此外，模型参数 rd 被确定对 CBE 具有最大影响，其他参数的影响适中。MKM_B 模型的开发使得能够在 BNCT 中不同硼分布下准确预测 CBE。该模型为通过提供更高的生物学有效性准确性来优化治疗计划提供了一种有前途的方法。
