Department of Clinical Microbiology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia..
Acta Med Indones. 2024 Apr;56(2):191-198.
Antibiotic resistance is the main problem in infectious disease management. Multidrug-resistant (MDR) bacteria could be carried by admitted patients and become a source of spread in the hospital, causing infections in other patients or the patients themselves. However, the screening of MDR bacteria has not been a standard in developing countries. This study aimed to get the prevalence of MDR bacteria colonization in patients on admission to Dr. Cipto Mangunkusumo Hospital.
Selective liquid media with added antibiotics were used for culturing the MDR bacteria. While admitted to the hospital, subjects were sampled and interviewed to fill out a questionnaire. The screening specimens used for this study were throat, navel, rectal, nasal, and armpit swabs. During hospitalization, hospital-acquired infections (HAIs) were recorded.
Of 100 patients included in the study, the prevalence of MDR bacteria colonization on admission was 63% (n=63) with the prevalence of CR-GNB, ESBL-PE, and MRSA were 11%, 54%, and 11%, respectively. Two-thirds of the patients with HAIs (n=8/12) were colonized with MDR bacteria. Factors associated with MDR bacteria colonization were the recent use of invasive medical devices and comorbidity, while a factor associated with CR-GNB colonization was the recent use of antibiotics.
The prevalence of MDR bacteria colonization in patients on admission to Dr. Cipto Mangunkusumo Hospital in 2022 was 63% (n=63), of which 12.68% (n=8) experienced HAIs during hospitalization. MDR bacteria colonization was associated with the recent use of invasive medical devices and comorbidity. History of antibiotic use was associated with CR-GNB colonization.
抗生素耐药性是传染病管理中的主要问题。耐多药（MDR）细菌可由入院患者携带，并成为医院内传播的源头，导致其他患者或患者自身感染。然而，在发展中国家，MDR 细菌的筛查尚未成为标准。本研究旨在了解 Cipto Mangunkusumo 医院入院患者中 MDR 细菌定植的流行情况。
使用添加抗生素的选择性液体培养基进行 MDR 细菌培养。患者入院时进行采样并接受访谈以填写问卷。本研究使用的筛查标本为咽喉、脐、直肠、鼻腔和腋窝拭子。住院期间记录医院获得性感染（HAI）。
在纳入研究的 100 名患者中，入院时 MDR 细菌定植的患病率为 63%（n=63），其中耐碳青霉烯类肠杆菌科细菌（CR-GNB）、超广谱β-内酰胺酶阳性肠杆菌科细菌（ESBL-PE）和耐甲氧西林金黄色葡萄球菌（MRSA）的患病率分别为 11%、54%和 11%。有 12 例 HAI（n=8/12）的患者定植了 MDR 细菌。与 MDR 细菌定植相关的因素是近期使用侵入性医疗器械和合并症，而与 CR-GNB 定植相关的因素是近期使用抗生素。
2022 年，Cipto Mangunkusumo 医院入院患者中 MDR 细菌定植的患病率为 63%（n=63），其中 12.68%（n=8）在住院期间发生 HAI。MDR 细菌定植与近期使用侵入性医疗器械和合并症有关。抗生素使用史与 CR-GNB 定植有关。
