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腰骶部X线参数的人工智能自动测量技术

Artificial intelligence automatic measurement technology of lumbosacral radiographic parameters.

作者信息

Yuan Shuo, Chen Ruiyuan, Liu Xingyu, Wang Tianyi, Wang Aobo, Fan Ning, Du Peng, Xi Yu, Gu Zhao, Zhang Yiling, Zang Lei

机构信息

Department of Orthopedics, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

School of Life Sciences, Tsinghua University, Beijing, China.

出版信息

Front Bioeng Biotechnol. 2024 Jul 1;12:1404058. doi: 10.3389/fbioe.2024.1404058. eCollection 2024.

Abstract

BACKGROUND

Currently, manual measurement of lumbosacral radiological parameters is time-consuming and laborious, and inevitably produces considerable variability. This study aimed to develop and evaluate a deep learning-based model for automatically measuring lumbosacral radiographic parameters on lateral lumbar radiographs.

METHODS

We retrospectively collected 1,240 lateral lumbar radiographs to train the model. The included images were randomly divided into training, validation, and test sets in a ratio of approximately 8:1:1 for model training, fine-tuning, and performance evaluation, respectively. The parameters measured in this study were lumbar lordosis (LL), sacral horizontal angle (SHA), intervertebral space angle (ISA) at L4-L5 and L5-S1 segments, and the percentage of lumbar spondylolisthesis (PLS) at L4-L5 and L5-S1 segments. The model identified key points using image segmentation results and calculated measurements. The average results of key points annotated by the three spine surgeons were used as the reference standard. The model's performance was evaluated using the percentage of correct key points (PCK), intra-class correlation coefficient (ICC), Pearson correlation coefficient (r), mean absolute error (MAE), root mean square error (RMSE), and box plots.

RESULTS

The model's mean differences from the reference standard for LL, SHA, ISA (L4-L5), ISA (L5-S1), PLS (L4-L5), and PLS (L5-S1) were 1.69°, 1.36°, 1.55°, 1.90°, 1.60%, and 2.43%, respectively. When compared with the reference standard, the measurements of the model had better correlation and consistency (LL, SHA, and ISA: ICC = 0.91-0.97, r = 0.91-0.96, MAE = 1.89-2.47, RMSE = 2.32-3.12; PLS: ICC = 0.90-0.92, r = 0.90-0.91, MAE = 1.95-2.93, RMSE = 2.52-3.70), and the differences between them were not statistically significant ( > 0.05).

CONCLUSION

The model developed in this study could correctly identify key vertebral points on lateral lumbar radiographs and automatically calculate lumbosacral radiographic parameters. The measurement results of the model had good consistency and reliability compared to manual measurements. With additional training and optimization, this technology holds promise for future measurements in clinical practice and analysis of large datasets.

摘要

背景

目前,腰骶部放射学参数的手动测量既耗时又费力,而且不可避免地会产生相当大的变异性。本研究旨在开发并评估一种基于深度学习的模型,用于在腰椎侧位X线片上自动测量腰骶部放射学参数。

方法

我们回顾性收集了1240张腰椎侧位X线片来训练模型。纳入的图像按照约8:1:1的比例随机分为训练集、验证集和测试集,分别用于模型训练、微调及性能评估。本研究中测量的参数包括腰椎前凸(LL)、骶骨水平角(SHA)、L4-L5和L5-S1节段的椎间隙角(ISA),以及L4-L5和L5-S1节段腰椎滑脱百分比(PLS)。该模型利用图像分割结果识别关键点并计算测量值。三位脊柱外科医生标注的关键点的平均结果用作参考标准。使用正确关键点百分比(PCK)、组内相关系数(ICC)、皮尔逊相关系数(r)、平均绝对误差(MAE)、均方根误差(RMSE)和箱线图评估模型性能。

结果

该模型与LL、SHA、ISA(L4-L5)、ISA(L5-S1)、PLS(L4-L5)和PLS(L5-S1)参考标准的平均差异分别为1.69°°、1.36°、1.55°、1.90°、1.60%和2.43%。与参考标准相比,该模型的测量值具有更好的相关性和一致性(LL、SHA和ISA:ICC = 0.91-0.97,r = 0.91-0.96,MAE = 1.89-2.47,RMSE = 2.32-3.12;PLS:ICC = 0.90-0.92,r = 0.90-0.91,MAE = 1.95-2.93,RMSE = 2.52-3.70),且它们之间的差异无统计学意义(>0.05)。

结论

本研究开发的模型能够正确识别腰椎侧位X线片上的关键椎体点,并自动计算腰骶部放射学参数。与手动测量相比,该模型的测量结果具有良好的一致性和可靠性。通过进一步训练和优化,这项技术有望在未来临床实践测量及大型数据集分析中发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65f6/11246908/56591fdc24a0/fbioe-12-1404058-g001.jpg

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