Wei Zhifeng, Wei Na, Su Long, Gao Sujun
Department of Hematology, The First Hospital of Jilin University, Changchun, China.
Department of Obstetrics, The Affiliated Taian City Central Hospital of Qingdao University, Taian, China.
Front Pharmacol. 2024 Jul 1;15:1407010. doi: 10.3389/fphar.2024.1407010. eCollection 2024.
As an increasingly well-known derivative of coumarin, daphnetin (7,8-dithydroxycoumarin) has demonstrated various pharmacological activities, including anti-inflammation, anti-cancer, anti-autoimmune diseases, antibacterial, organ protection, and neuroprotection properties. Various studies have been conducted to explore the action mechanisms and synthetic methods of daphnetin, given its therapeutic potential in clinical. Despite these initial insights, the precise mechanisms underlying the pharmacological activities of daphnetin remain largely unknown. In order to address this knowledge gap, we explore the molecular effects from the perspectives of signaling pathways, NOD-like receptor protein 3 (NLRP3) inflammasome and inflammatory factors; and try to find out how these mechanisms can be utilized to inform new combined therapeutic strategies.
作为香豆素一种日益知名的衍生物，瑞香素（7,8 - 二羟基香豆素）已展现出多种药理活性，包括抗炎、抗癌、抗自身免疫性疾病、抗菌、器官保护及神经保护特性。鉴于瑞香素在临床上的治疗潜力，人们已开展了各种研究来探索其作用机制和合成方法。尽管有这些初步认识，但瑞香素药理活性背后的确切机制仍大多未知。为了填补这一知识空白，我们从信号通路、NOD样受体蛋白3（NLRP3）炎性小体和炎性因子的角度探索其分子效应；并试图找出如何利用这些机制来制定新的联合治疗策略。
