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调控与治疗：JAK2/STAT3 信号通路在骨关节炎中的作用：系统综述。

Regulation and therapy, the role of JAK2/STAT3 signaling pathway in OA: a systematic review.

机构信息

College of Exercise and Health, Shenyang Sport University, Shenyang, China.

出版信息

Cell Commun Signal. 2023 Apr 3;21(1):67. doi: 10.1186/s12964-023-01094-4.

DOI:10.1186/s12964-023-01094-4
PMID:37013568
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10071628/
Abstract

Osteoarthritis (OA) is a multifactorial chronic disease primarily characterized by the degeneration of articular cartilage. Currently, there is a lack of effective treatments for OA other than surgery. The exploration of the mechanisms of occurrence is important in exploring other new and effective treatments for OA. The current evidence shows that the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway plays a vital role in cytogenesis and is involved in OA progression. The terms "JAK2", "STAT3", and "Osteoarthritis"were used in a comprehensive literature search in PubMed to further investigate the relationship between the JAK2/STAT3 signaling pathway and OA. This review focuses on the role and mechanism of JAK2/STAT3 signaling in cartilage degradation, subchondral bone dysfunction, and synovial inflammation. In addition, this review summarizes recent evidence of therapeutic approaches to treat OA by targeting the JAK2/STAT3 pathway to accelerate the translation of evidence into the progression of strategies for OA treatment. Video abstract.

摘要

骨关节炎（OA）是一种多因素的慢性疾病，主要特征为关节软骨退化。目前，除手术外，OA 缺乏有效的治疗方法。探讨发病机制对于探索 OA 的其他新的有效治疗方法很重要。目前的证据表明，Janus 激酶 2（JAK2）/信号转导和转录激活因子 3（STAT3）信号通路在细胞发生中起着至关重要的作用，并参与 OA 的进展。在 PubMed 中使用“JAK2”、“STAT3”和“骨关节炎”等术语进行全面文献检索，以进一步研究 JAK2/STAT3 信号通路与 OA 之间的关系。本综述重点介绍了 JAK2/STAT3 信号在软骨降解、软骨下骨功能障碍和滑膜炎症中的作用和机制。此外，本综述总结了最近通过靶向 JAK2/STAT3 通路治疗 OA 的治疗方法的证据，以加速证据转化为 OA 治疗策略的进展。视频摘要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ff/10071628/2c2f6e5b476f/12964_2023_1094_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ff/10071628/69b34c019991/12964_2023_1094_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ff/10071628/f4770a7d90b6/12964_2023_1094_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ff/10071628/f46da9327dbd/12964_2023_1094_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ff/10071628/2c2f6e5b476f/12964_2023_1094_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ff/10071628/69b34c019991/12964_2023_1094_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ff/10071628/f4770a7d90b6/12964_2023_1094_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ff/10071628/f46da9327dbd/12964_2023_1094_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ff/10071628/2c2f6e5b476f/12964_2023_1094_Fig4_HTML.jpg

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[5]
Integrative in silico and in vivo Drosophila model studies reveal the anti-inflammatory, antioxidant, and anticancer properties of red radish microgreen extract.

Sci Rep. 2025-5-27

[6]
DNA Origami-Based CD44-Targeted Therapy Silences Stat3 Enhances Cartilage Regeneration and Alleviates Osteoarthritis Progression.

Adv Sci (Weinh). 2025-8

[7]
JAK2/STAT3/HMGCS2 signaling aggravates mitochondrial dysfunction and oxidative stress in hyperuricemia-induced cardiac dysfunction.

Mol Med. 2025-5-13

[8]
Corticosterone effects induced by stress and immunity and inflammation: mechanisms of communication.

Front Endocrinol (Lausanne). 2025-3-20

[9]
STAT3 Signaling Pathway in Health and Disease.

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[10]
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本文引用的文献

[1]
Stat3 Signaling Pathway: A Future Therapeutic Target for Bone-Related Diseases.

Front Pharmacol. 2022-4-25

[2]
Leptin Induced TLR4 Expression via the JAK2-STAT3 Pathway in Obesity-Related Osteoarthritis.

Oxid Med Cell Longev. 2021-8-17

[3]
The Protective Effects of Parathyroid Hormone (1-34) on Cartilage and Subchondral Bone Through Down-Regulating JAK2/STAT3 and WNT5A/ROR2 in a Collagenase-Induced Osteoarthritis Mouse Model.

Orthop Surg. 2021-7

[4]
The JAK inhibitor Tofacitinib inhibits structural damage in osteoarthritis by modulating JAK1/TNF-alpha/IL-6 signaling through Mir-149-5p.

Bone. 2021-10

[5]
Knockdown of hsa_circ_0134111 alleviates the symptom of osteoarthritis via sponging microRNA-224-5p.

Cell Cycle. 2021-6

[6]
Subchondral bone microenvironment in osteoarthritis and pain.

Bone Res. 2021-3-17

[7]
INSR mediated by transcription factor KLF4 and DNA methylation ameliorates osteoarthritis progression via inactivation of JAK2/STAT3 signaling pathway.

Am J Transl Res. 2020-12-15

[8]
Osteoarthritis of the Knee.

N Engl J Med. 2021-1-7

[9]
Hypoxic pretreatment of small extracellular vesicles mediates cartilage repair in osteoarthritis by delivering miR-216a-5p.

Acta Biomater. 2021-3-1

[10]
CircSOD2 induced epigenetic alteration drives hepatocellular carcinoma progression through activating JAK2/STAT3 signaling pathway.

J Exp Clin Cancer Res. 2020-11-25

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