Fujian Provincial Key Laboratory of Polymer Materials, College of Chemistry and Materials Science, Fujian Normal University, Fuzhou, Fujian, 350117, P. R. China.
College of Chemical Engineering and Materials Science, Quanzhou Normal University, Quanzhou, Fujian, 362046, P. R. China.
Small. 2024 Nov;20(45):e2402641. doi: 10.1002/smll.202402641. Epub 2024 Jul 16.
The tracking of nanomedicines in their concentration and location inside living systems has a pivotal effect on the understanding of the biological processes, early-stage diagnosis, and therapeutic monitoring of diseases. Nanoscale metal-organic frameworks (nano MOFs) possess high surface areas, definite structure, regulated optical properties, rich functionalized sites, and good biocompatibility that allow them to excel in a wide range of biomedical applications. Controllable syntheses and functionalization endow nano MOFs with better properties as imaging agents and sensing units for the diagnosis and treatment of diseases. This minireview summarizes the tunable synthesis strategies of nano MOFs with controllable size, shape, and regulated luminescent performance, and pinpoints their recent advanced applications as optical elements in bioimaging and biosensing. The current limitations and future development directions of nano MOF-contained materials in bioimaging and biosensing applications are also discussed, aiming to expand the biological applications of nano MOF-based nanomedicine and facilitate their production or clinical translation.
纳米医学在活体内的浓度和位置的追踪对生物过程的理解、疾病的早期诊断和治疗监测具有关键作用。纳米尺度的金属-有机骨架（nano MOFs）具有高比表面积、确定的结构、可调节的光学性质、丰富的功能化位点和良好的生物相容性，使它们在广泛的生物医学应用中表现出色。可控合成和功能化使纳米 MOFs 成为成像剂和传感单元，用于疾病的诊断和治疗。这篇综述总结了具有可控尺寸、形状和调节发光性能的纳米 MOFs 的可调合成策略，并指出了它们最近作为生物成像和生物传感光学元件的先进应用。还讨论了纳米 MOF 包含的材料在生物成像和生物传感应用中的当前限制和未来发展方向，旨在扩展基于纳米 MOF 的纳米医学的生物学应用，并促进其生产或临床转化。
