Attiach Célest M, Kumar Amit, Daniel Jonathan, Blanchard-Desce Mireille, Maruani Antoine, Dalko Peter I
Université Paris Cité, CNRS, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, 75006 Paris, France.
Univ. Bordeaux, CNRS, Bordeaux INP, ISM, UMR 5255, F-33400 Talence, France.
Chem Commun (Camb). 2024 Aug 1;60(63):8260-8263. doi: 10.1039/d4cc02852j.
Herein we describe the rational design, synthesis and photophysical study of a novel class of phenanthridine-based, one- and two-photon sensitive, photoremovable protecting groups with absorption wavelengths extending beyond 400 nm. This design facilitated the development of scaffolds with enhanced uncaging quantum yield, paving the way for broader applications in controlled drug delivery and molecular manipulation.
在此，我们描述了一类新型的基于菲啶的单光子和双光子敏感的光可去除保护基团的合理设计、合成及光物理研究，其吸收波长超过400 nm。这种设计促进了具有更高解笼量子产率的支架的开发，为在可控药物递送和分子操纵中的更广泛应用铺平了道路。
