Master Study Program of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
Eur Rev Med Pharmacol Sci. 2024 Jul;28(13):3922-3933. doi: 10.26355/eurrev_202407_36524.
Preeclampsia (PE) affects only about 10% of women who meet the criteria for obesity based on their body mass index (BMI). Obesity is suggested to play a role in preeclampsia pathophysiology, and in addition to BMI, associated biomarkers with higher sensitivity and specificity, such as with adipokines from adipose tissue, are needed to enable clinical risk assessment. This study aimed to investigate obese pregnant women with and without PE by comparing clinical profiles and adipokine profiles specific to general adipose tissue (adiponectin and leptin).
This meta-analysis was conducted following the PRISMA and was registered in PROSPERO (CRD42023478706). We utilized Cochrane, Scopus, and PubMed/Medline databases. The Cochrane ROBINS-I instrument was employed to assess the quality of studies. Pooled standard mean difference (SMD) and p-value were analyzed using a random-effects model with the DerSimonian-Laird method, while subgroup analysis with the Chi-square test and the inconsistency index (I2) were used to assess potential sources of heterogeneity.
Three observational studies included a total of 2,646 obese pregnant women and found that adiponectin was more likely to have a lower level in pregnant women with obesity [SMD=-0.32; 95% CI: -0.34-0.17, p=0.003] and leptin was more likely to be higher in obese pregnant women with PE rather than non-PE [SMD=0.53; 95% CI: -0.19-1.08, p<0.00001].
Adiponectin levels were more likely to be lower in pregnant women with obesity in the PE group than in the non-PE group, and leptin levels were more likely to be higher.
子痫前期（PE）仅影响约 10%符合体重指数（BMI）肥胖标准的女性。肥胖被认为在子痫前期病理生理学中起作用，除了 BMI 外，还需要具有更高灵敏度和特异性的相关生物标志物，例如来自脂肪组织的脂肪因子，以进行临床风险评估。本研究旨在通过比较患有和不患有 PE 的肥胖孕妇的临床特征和特定于一般脂肪组织的脂肪因子（脂联素和瘦素）来研究这一问题。
本荟萃分析遵循 PRISMA 原则，并在 PROSPERO（CRD42023478706）中进行了注册。我们使用了 Cochrane、Scopus 和 PubMed/Medline 数据库。使用 Cochrane ROBINS-I 工具评估研究质量。使用随机效应模型和 DerSimonian-Laird 方法分析汇总标准均数差（SMD）和 p 值，使用卡方检验和不一致指数（I2）进行亚组分析，以评估潜在的异质性来源。
三项观察性研究共纳入 2646 名肥胖孕妇，结果发现脂联素在肥胖孕妇中更有可能处于较低水平[SMD=-0.32；95%CI：-0.34-0.17，p=0.003]，而瘦素在肥胖孕妇中更有可能在患有 PE 而非非 PE 时更高[SMD=0.53；95%CI：-0.19-1.08，p<0.00001]。
PE 组肥胖孕妇的脂联素水平更有可能低于非 PE 组，而瘦素水平更有可能升高。
