Department of Chemistry, University of York, York YO10 5DD, UK.
GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK.
Org Biomol Chem. 2024 Jul 31;22(30):6149-6155. doi: 10.1039/d4ob00939h.
The unspecific peroxygenase (UPO) from (rUPO-PaDa-I-H) is an effective and practical biocatalyst for the oxidative expansion of furfuryl alcohols/amines on a preparative scale, using the Achmatowicz and aza-Achmatowicz reaction. The high activity and stability of the enzyme, which can be produced on a large scale as an air-stable lyophilised powder, renders it a versatile and scalable biocatalyst for the preparation of synthetically valuable 6-hydroxypyranones and dihydropiperidinones. In several cases, the biotransformation out-performed the analogous chemo-catalysed process, and operates under milder and greener reaction conditions.
（rUPO-PaDa-I-H）中的非特异性过氧化物酶（UPO）是一种有效的、实用的生物催化剂，可用于阿赫马托维奇和氮杂阿赫马托维奇反应，在制备规模上氧化扩展糠醇/胺。该酶具有较高的活性和稳定性，可作为一种空气稳定的冻干粉末大规模生产，使其成为一种多功能、可扩展的生物催化剂，可用于制备具有合成价值的 6-羟基-2-吡喃酮和二氢哌啶酮。在几种情况下，生物转化的效果优于类似的化学催化过程，并且在更温和、更环保的反应条件下进行。
