Internal Medicine, Shaheed Mohtarma Benazir Bhutto Medical College Lyari Karachi, , H#565-66F/46, Khokhar Mohallah, Hyderabad, Pakistan.
Internal Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.
Support Care Cancer. 2024 Jul 16;32(8):515. doi: 10.1007/s00520-024-08703-z.
This meta-analysis examined the effectiveness of exercise interventions in reducing fatigue and depression among women undergoing chemotherapy for breast cancer. The study followed PRISMA guidelines and analysed seven randomized controlled trials between 2016 and 2022. The results showed that exercise can substantially reduce fatigue levels (MD: -0.40, CI: -0.66, -0.14, P: 0.003), a common side effect of chemotherapy. Although depression did not significantly change (MD: -0.39, CI: -0.98, 0.20, P: 0.19), this study highlights the positive impact of exercise on mental health outcomes. The control group also experienced decreased quality of life (MD: 0.18, CI: 0.01-0.35, P: 0.03), emphasizing the importance of incorporating exercise interventions to improve overall well-being during breast cancer treatment. In addition to primary outcomes, the study revealed that exercise positively affected secondary aspects such as cognitive fatigue, social function, physical function, constipation, and dyspnoea.
这项荟萃分析考察了运动干预在减轻女性乳腺癌化疗后疲劳和抑郁的有效性。该研究遵循 PRISMA 指南，分析了 2016 年至 2022 年期间的 7 项随机对照试验。结果表明，运动可以显著降低疲劳水平（MD：-0.40，CI：-0.66，-0.14，P：0.003），这是化疗的常见副作用。虽然抑郁程度没有显著变化（MD：-0.39，CI：-0.98，0.20，P：0.19），但本研究强调了运动对心理健康结果的积极影响。对照组的生活质量也有所下降（MD：0.18，CI：0.01-0.35，P：0.03），这强调了在乳腺癌治疗期间纳入运动干预以提高整体幸福感的重要性。除了主要结果外，该研究还表明，运动对认知疲劳、社会功能、身体功能、便秘和呼吸困难等次要方面也有积极影响。
