Department of Pharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, Kraków, Poland.
Department of Neuropsychopharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, Kraków, Poland.
Pharmacol Rep. 2024 Oct;76(5):1044-1054. doi: 10.1007/s43440-024-00626-0. Epub 2024 Jul 16.
Iron is one of the key microelements in the mammalian body and is the most abundant metal in the brain. Iron, a very important chemical element in the body of mammals, is the most abundant metal in the brain. It participates in many chemical reactions taking place in the central nervous system acting as a cofactor in key enzymatic reactions involved in neurotransmitter synthesis and degradation, dendritic arborization, and myelination. Moreover, iron accumulation in the brain has been implicated in the pathogenesis of neurogenerative disorders.
The aim of our study was to assess the influence of iron administered orally (30 mg/kg) to rats in the neonatal period (p12-p14) by testing the performance of rats in the open field and social interaction tests, and by evaluating the recognition memory, monoamine levels in some brain structures, and BDNF mRNA expression. The behavioral and biochemical tests were performed in adult p88-p92 rats.
Iron administered to rats in the neonatal period induced long-term deficits in behavioral tests in adult rats. It reduced the exploratory activity in the open field test. In the social interaction test, it induced deficits in the parameters studied, and decreased memory retention. Moreover, iron changed the brain monoamine levels in some studied brain structures and decreased the expression of BDNF mRNA in the hippocampus.
All earlier and our present results indicated that iron administered to rats in the neonatal period induced an increase in oxidative stress which resulted in a change in the brain monoamine levels and decreased BDNF mRNA expression which may play a role in iron-induced memory impairment in adult rats.
铁是哺乳动物体内的关键微量元素之一，也是大脑中含量最丰富的金属。铁是哺乳动物体内非常重要的化学元素，也是大脑中含量最丰富的金属。它作为关键酶反应的辅助因子参与中枢神经系统中的许多化学反应，参与神经递质合成和降解、树突分支和髓鞘形成。此外，铁在大脑中的积累与神经退行性疾病的发病机制有关。
我们的研究目的是通过测试大鼠在旷场和社交互动测试中的表现，以及评估识别记忆、某些脑结构中的单胺水平和 BDNF mRNA 表达，来评估铁在新生期（p12-p14）经口给予（30mg/kg）对大鼠的影响。行为和生化测试在成年 p88-p92 大鼠中进行。
新生期给予大鼠的铁在成年大鼠的行为测试中诱导了长期缺陷。它减少了旷场测试中的探索活动。在社交互动测试中，它诱导了所研究参数的缺陷，并降低了记忆保留。此外，铁改变了某些研究脑结构中的脑单胺水平，并降低了海马体中的 BDNF mRNA 表达。
所有早期和我们目前的结果表明，新生期给予大鼠的铁诱导氧化应激增加，导致脑单胺水平发生变化，BDNF mRNA 表达降低，这可能在成年大鼠铁诱导的记忆损伤中起作用。
