Imai Ryota, Tanaka So, Kubo Takanari, Hida Mitsumasa, Nakao Hidetoshi, Imaoka Masakazu, Nishigami Tomohiko
Graduate School of Rehabilitation, Osaka Kawasaki Rehabilitation University, 158 Mizuma, Kaizuka City, Osaka, 597-0104, Japan.
Department of Clinical Research Center, Fukuoka Orthopaedic Hospital, 2-10-50 Yanagochi, Minami-ku, Fukuoka, Fukuoka, 815-0063, Japan.
Eur Geriatr Med. 2024 Oct;15(5):1449-1459. doi: 10.1007/s41999-024-01018-6. Epub 2024 Jul 16.
Neuroinflammation, which occurs in knee osteoarthritis and sarcopenia, has attracted attention as a mechanism of central sensitization, but the relationship between central sensitization and these conditions has not been widely studied. This study investigates differences in self-reported signs of central sensitization and pressure pain threshold in individuals with knee osteoarthritis and sarcopenia.
We examined 340 patients (mean age ± standard deviation: 76 ± 5.9, women were 86.9%) with knee osteoarthritis scheduled to undergo total knee arthroplasty. For comparison, 129 community-dwelling older people (mean age ± standard deviation: 76 ± 5.5, women were 68.9%) individuals without a history of knee osteoarthritis or any other diagnosed illnesses were matched for age and sex. We assessed central sensitization inventory-9, pressure pain threshold, pain-related factors, skeletal muscle mass index, and hand grip strength. ANCOVA using 2 (patients with knee osteoarthritis and community older people without knee osteoarthritis) × 2 (sarcopenia and robust) was performed to assess outcome measurements.
The prevalence of sarcopenia among patients with knee osteoarthritis was 50.3%. ANCOVA revealed an interaction effect for the central sensitization inventory-9. For the main effect of knee osteoarthritis, there was a significant difference in central sensitization inventory-9, and for the main effect of sarcopenia, there was a significant difference in pressure pain threshold.
Discrepancies in the evaluation of central sensitization were identified between knee osteoarthritis and sarcopenia. Individuals with knee osteoarthritis had elevated score of self-reported indications of central sensitization, whereas sarcopenic patients had reduced pressure pain thresholds.
神经炎症发生于膝关节骨关节炎和肌肉减少症中，作为中枢敏化的一种机制已受到关注，但中枢敏化与这些病症之间的关系尚未得到广泛研究。本研究调查膝关节骨关节炎和肌肉减少症患者自我报告的中枢敏化体征及压痛阈值的差异。
我们检查了340例计划接受全膝关节置换术的膝关节骨关节炎患者（平均年龄±标准差：76±5.9岁，女性占86.9%）。作为对照，选取了129名社区居住的老年人（平均年龄±标准差：76±5.5岁，女性占68.9%），这些人无膝关节骨关节炎病史或任何其他已确诊疾病，且在年龄和性别上进行了匹配。我们评估了中枢敏化量表-9、压痛阈值、疼痛相关因素、骨骼肌质量指数和握力。采用2（膝关节骨关节炎患者和无膝关节骨关节炎的社区老年人）×2（肌肉减少症和健康）的协方差分析来评估结果指标。
膝关节骨关节炎患者中肌肉减少症的患病率为50.3%。协方差分析显示中枢敏化量表-9存在交互作用。对于膝关节骨关节炎的主效应，中枢敏化量表-9存在显著差异；对于肌肉减少症的主效应，压痛阈值存在显著差异。
在膝关节骨关节炎和肌肉减少症之间发现了中枢敏化评估的差异。膝关节骨关节炎患者自我报告的中枢敏化指标得分升高，而肌肉减少症患者的压痛阈值降低。
