Department of Nuclear Medicine, Beijing Chaoyang Hospital, Capital Medical University, 8th Gongtinanlu Road, Chaoyang District, Beijing, 100020, China.
Department of Hematology, Beijing Chaoyang Hospital, Capital Medical University, 8th Gongtinanlu Road, Chaoyang District, Beijing, 100020, China.
Ann Hematol. 2024 Oct;103(10):4145-4153. doi: 10.1007/s00277-024-05888-5. Epub 2024 Jul 16.
This study aimed to assess the prognostic value of F-fluorodeoxyglucose positron emission tomography/computer tomography (F-FDG PET/CT) in patients with relapsed multiple myeloma (MM). Fifty-one consecutive patients with relapsed MM were enrolled in this retrospective study. F-FDG parameters based on the Italian Myeloma Criteria for PET Use (IMPeTUs) and clinical data were analyzed for overall survival (OS) and progression-free survival (PFS). The Cox proportional risk model was used for univariate and multivariate analysis, and Kaplan-Meier survival curves were used for survival analysis. The median length of follow-up was 20 months (IQR, 5-29 months), the median PFS for the entire cohort was 8 months (IQR, 3-17 months) and the median OS was 21 months (IQR, 8-49 months). Multivariate survival analysis demonstrated that the Deauville score of BM > 3 [HR 2.900, 95% CI (1.011, 8.319), P = 0.048] and the presence of EMD [HR 3.134, 95% CI (1.245, 7.891), P = 0.015] were independent predictors of poor PFS. The presence of EMD [HR 12.777, 95% CI (1.825, 89.461), P = 0.010] and the reduced platelets count [HR 7.948, 95% CI (1.236, 51.099), P = 0.029] were adversely associated with OS. F-FDG PET/CT parameters based on IMPeTUs have prognostic significance in patients with relapsed MM.
这项研究旨在评估氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（F-FDG PET/CT）在复发性多发性骨髓瘤（MM）患者中的预后价值。本回顾性研究纳入了 51 例复发性 MM 患者。对基于意大利多发性骨髓瘤 PET 使用标准（IMPeTUs）的 F-FDG 参数和临床数据进行分析，以评估总生存期（OS）和无进展生存期（PFS）。使用Cox 比例风险模型进行单因素和多因素分析，并使用 Kaplan-Meier 生存曲线进行生存分析。中位随访时间为 20 个月（IQR，5-29 个月），整个队列的中位 PFS 为 8 个月（IQR，3-17 个月），中位 OS 为 21 个月（IQR，8-49 个月）。多因素生存分析表明，BM 中 Deauville 评分>3[HR 2.900，95%CI（1.011，8.319），P=0.048]和存在 EMD[HR 3.134，95%CI（1.245，7.891），P=0.015]是 PFS 不良的独立预测因素。存在 EMD[HR 12.777，95%CI（1.825，89.461），P=0.010]和血小板计数减少[HR 7.948，95%CI（1.236，51.099），P=0.029]与 OS 不良相关。基于 IMPeTUs 的 F-FDG PET/CT 参数在复发性 MM 患者中具有预后意义。
