确定2019年至2022年期间在斯里兰卡西部省份传播的登革热菌株。
Identifying the strains of dengue circulating in the western province of Sri Lanka during 2019-2022.
作者信息
Abeygoonawardena Harshi, Dassanayake Kanchana, Kariyawasam Jayani, Chathuranga Teshan, Sundralingam Tharmini, Gunasekara Hansani, Wevita Sathyani, Premawansa Gayani, Premawansa Sunil, Wijewickrama Ananda, Wijesinghe Namal, Navaratne Varuna, Weiskopf Daniela, Sette Alessandro, Punchihewa Chandanamali, De Silva Aruna Dharshan
机构信息
Faculty of Medicine, General Sir John Kotelawala Defence University, Kandawala Estate Ratmalana, Sri Lanka.
Genelabs Medical (Pvt) Ltd, Nawala Rd, Nawala, Sri Lanka.
出版信息
PLOS Glob Public Health. 2024 Jul 16;4(7):e0003150. doi: 10.1371/journal.pgph.0003150. eCollection 2024.
A study conducted from July 2019 to May 2022 at several hospitals in the Western Province, Sri Lanka, focused on dengue virus strains during the COVID-19 pandemic. Among 417 febrile patients, 47% were PCR-positive for dengue. Serotyping revealed DENV-1 (12.8%), DENV-2 (46.4%), DENV-3 (37.2%), and DENV-4 (3.6%). Sequencing identified two genotypically distinct variants of DENV-3 and two genotypically distinct variants of DENV-1, while DENV-2 showed a single genotype cluster. Notably, the study found concurrent circulation of two DENV-3 and two DENV-1 genotypes, along with DENV-2, during the pandemic in the area. This data suggests the presence of multiple dengue strains, including several DENV-1 and DENV-3 variants, without major epidemic outbreaks reported in the Western Province. Continuous monitoring and research are essential to understand the dynamics of these dengue strains in the context of the COVID-19 pandemic.
2019年7月至2022年5月在斯里兰卡西部省份的几家医院进行的一项研究聚焦于新冠疫情期间的登革病毒株。在417名发热患者中，47%的登革热PCR检测呈阳性。血清分型显示为登革病毒1型（12.8%）、登革病毒2型（46.4%）、登革病毒3型（37.2%）和登革病毒4型（3.6%）。测序确定了登革病毒3型的两个基因不同的变体以及登革病毒1型的两个基因不同的变体，而登革病毒2型显示为单一基因型簇。值得注意的是，该研究发现该地区在疫情期间登革病毒3型的两个基因型、登革病毒1型的两个基因型与登革病毒2型同时传播。这些数据表明存在多种登革病毒株，包括几种登革病毒1型和登革病毒3型变体，而西部省份未报告重大疫情爆发。持续监测和研究对于了解新冠疫情背景下这些登革病毒株的动态至关重要。
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