Gastroenterology and Urology Department Ⅱ, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, Hunan 410013, China; Cancer Research Institute, Basic School of Medicine, Central South University, Changsha, Hunan 410011, China.
Cancer Research Institute, Basic School of Medicine, Central South University, Changsha, Hunan 410011, China.
Biomed Pharmacother. 2024 Aug;177:117146. doi: 10.1016/j.biopha.2024.117146. Epub 2024 Jul 15.
Folliculin interacting protein 1 (FNIP1), a novel folliculin interacting protein 1, is a key regulatory factor for mitochondrial function. FNIP1 mainly responds to energy signal transduction through physical interactions with 5'-AMP activated protein kinase (AMPK). Simultaneously, it affects the transcription of mitochondria-associated genes by regulating the lysosomal localization of mechanistic target of rapamycin kinase (mTORC1). This article takes FNIP1 as the core and first introduces its involvement in the development of B cells and invariant natural killer T (iNKT) cells, muscle fiber type conversion, and the thermogenic remodeling of adipocytes by regulating mitochondrial function. In addition we discuss the detailed impact of upstream regulatory factors of FNIP1 on its function. Finally, the impact of FNIP1 on the prognosis and treatment of clinically related metabolic diseases is summarized, aiming to provide a new theoretical basis and treatment plans for the diagnosis and treatment of such diseases.
卵泡抑素相关蛋白 1（FNIP1）是一种新型的卵泡抑素相互作用蛋白 1，是调节线粒体功能的关键调节因子。FNIP1 主要通过与 5'-AMP 激活蛋白激酶（AMPK）的物理相互作用来响应能量信号转导。同时，它通过调节机械靶蛋白激酶（mTORC1）的溶酶体定位来影响与线粒体相关的基因的转录。本文以 FNIP1 为核心，首先介绍了它通过调节线粒体功能在 B 细胞和不变自然杀伤 T(iNKT)细胞的发育、肌纤维类型转换以及脂肪细胞的产热重塑中的作用。此外，我们还讨论了 FNIP1 的上游调节因子对其功能的详细影响。最后，总结了 FNIP1 对临床相关代谢性疾病预后和治疗的影响，旨在为这些疾病的诊断和治疗提供新的理论基础和治疗方案。
