Timofte Daniel Vasile, Tudor Razvan Cosmin, Mocanu Veronica, Labusca Luminita
Department of Surgery, "Grigore T. Popa" University of Medicine and Pharmacy, 16, Universitatii Street, 700115 Iasi, Romania.
Dr. Iacob Czihac Military Emergency Hospital Iasi, General Henri Mathias Berthelot Str. 7-9, 700483 Iași, Romania.
Nutrients. 2024 Dec 7;16(23):4231. doi: 10.3390/nu16234231.
Obesity and osteoarthritis (OA) are increasingly prevalent conditions that are intricately linked, with each exacerbating the other's pathogenesis and worsening patient outcomes. This review explores the dual impact of obesity on OA, highlighting the role of excessive weight in aggravating joint degeneration and the limitations OA imposes on physical activity, which further perpetuates obesity. The role of muscle tissue, particularly the release of myokines during physical activity, is examined in the context of OA and obesity. Myokines such as irisin, IL-6, and myostatin are discussed for their roles in metabolic regulation, inflammation, and tissue repair, offering insights into their potential therapeutic targets. This review emphasizes the importance of supervised weight management methods in parallel with muscle rehabilitation in improving joint health and metabolic balance. The potential for myokine modulation through targeted exercise and weight loss interventions to mitigate the adverse effects of obesity and OA is also discussed, suggesting avenues for future research and therapy development to reduce the burden of these chronic conditions.
肥胖症和骨关节炎（OA）是日益普遍的疾病，二者紧密相连，相互加剧对方的发病机制并恶化患者预后。本综述探讨了肥胖对OA的双重影响，强调了超重在加重关节退变中的作用以及OA对身体活动的限制，而这种限制又进一步使肥胖持续存在。在OA和肥胖症的背景下，研究了肌肉组织的作用，特别是在体育活动中肌动蛋白的释放。讨论了鸢尾素、白细胞介素-6和肌肉生长抑制素等肌动蛋白在代谢调节、炎症和组织修复中的作用，为其潜在的治疗靶点提供了见解。本综述强调了在进行肌肉康复的同时采用有监督的体重管理方法对于改善关节健康和代谢平衡的重要性。还讨论了通过有针对性的运动和减肥干预来调节肌动蛋白以减轻肥胖症和OA不良影响的潜力，为未来研究和治疗方法的开发指明了方向，以减轻这些慢性病的负担。
