IrsiCaixa Immunopathology Research Institute, 08916 Badalona, Spain; CIBERINFEC, 28029 Madrid, Spain; Germans Trias i Pujol Research Institute (IGTP), 08916 Badalona, Spain.
Laboratory of Immunoregulation, Division of Intramural Research, and Collaborative Clinical Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Med. 2024 Sep 13;5(9):1071-1082. doi: 10.1016/j.medj.2024.06.008. Epub 2024 Jul 15.
Exceptional elite controllers represent an extremely rare group of people with HIV-1 (PWH) who exhibit spontaneous, high-level control of viral replication below the limits of detection in sensitive clinical monitoring assays and without disease progression in the absence of antiretroviral therapy for prolonged periods, frequently exceeding 25 years. Here, we discuss the different cases that have been reported in the scientific literature, their unique genetic, virological, and immunological characteristics, and their relevance as the best model for the functional cure of HIV-1.
精英控制者是一个极其罕见的群体，他们代表了一小部分 HIV-1（艾滋病毒感染者）感染者，这些感染者在没有抗逆转录病毒治疗的情况下，能够在长时间内（通常超过 25 年）自发地将病毒复制控制在灵敏临床监测检测限以下，达到无法检测的高水平，且没有疾病进展。在这里，我们讨论了科学文献中报道的不同病例，以及它们独特的遗传、病毒学和免疫学特征，它们是 HIV-1 功能性治愈的最佳模型。
