School of Nursing and Rehabilitation, Nantong University, Nantong, Jiangsu, China.
Medical School of Nantong University, Nantong, Jiangsu 226007, China.
Neurotoxicology. 2024 Jul;103:335-357. doi: 10.1016/j.neuro.2024.07.006. Epub 2024 Jul 14.
Considering that endocrine disruptors have certain effects on fetal growth, we conducted a systematic review of epidemiological literature to elucidate the correlation between exposure to endocrine-disrupting chemicals during pregnancy and the neurodevelopment of offspring.
We systematically explored PubMed, Web of Science, and CINAHL databases from inception to April 4, 2023. References from pertinent studies were reviewed, and data regarding the link between maternal prenatal EDC exposure and offspring neurological development were compiled. A domain-based approach was used to evaluate studies of neurodevelopmental effects in children ≤3 years old by two reviewers, including cognition, motor, behavior, language, and non-verbal ability.
A comprehensive search yielded 45,373 articles, from which 48 articles, involving 26,005 mother-child pairs, met the criteria and were subsequently included in our analysis. The results revealed that EDC exposure during pregnancy had a significant impact on offspring neurobehavior development, especially in cognition, motor, and language. Our findings indicated adverse associations between prenatal exposure to metals and offspring cognition (before 12 months: β coefficient: -0.28; 95 % CI, -0.50 to -0.06; 1-3 years old: β coefficient: -0.55; 95 % CI: -1.08 to -0.02). Furthermore, metals (β coefficient: -0.71; 95 % CI: -1.23 to -0.19) and phthalates (β coefficient: -0.69; 95 % CI: -1.05 to -0.33) exposure exhibited detrimental effects on motor development from1-3 years old, while poly-fluoroalkyl substances were linked to the disruption of offspring language development (β coefficient: -1.01; 95 % CI: -1.90 to -0.11) within this timeframe. Additionally, exposure to EDCs during pregnancy had a negative impact on cognition development among girls from 12 to 36 months of age (β coefficient: -0.53; 95 % CI: -1.01 to -0.06).
Prenatal exposure to EDCs, especially metals, phthalates and, poly-fluoroalkyl substances, was associated with disrupting the development of offspring neurobehavior in the short and long term. Additionally, cognitive development showed gender differences due to prenatal endocrine-disrupting chemicals exposure.
考虑到内分泌干扰物对胎儿生长有一定影响，我们系统地回顾了流行病学文献，以阐明怀孕期间接触内分泌干扰化学物质与后代神经发育之间的关系。
我们系统地检索了 PubMed、Web of Science 和 CINAHL 数据库，检索时间截至 2023 年 4 月 4 日。查阅了相关研究的参考文献，并收集了母体产前暴露于内分泌干扰物与后代神经发育之间关系的数据。两位评估者采用基于领域的方法评估了 3 岁以下儿童神经发育效应的研究，包括认知、运动、行为、语言和非语言能力。
全面检索得到 45373 篇文章，其中 48 篇文章（涉及 26005 对母婴）符合纳入标准，并随后纳入分析。结果表明，怀孕期间接触内分泌干扰物对后代神经行为发育有显著影响，特别是在认知、运动和语言方面。我们的研究结果表明，产前暴露于金属与后代认知之间存在不良关联（12 个月前：β系数：-0.28；95%置信区间，-0.50 至-0.06；1-3 岁：β系数：-0.55；95%置信区间：-1.08 至-0.02）。此外，金属（β系数：-0.71；95%置信区间：-1.23 至-0.19）和邻苯二甲酸酯（β系数：-0.69；95%置信区间：-1.05 至-0.33）暴露从 1 岁至 3 岁对运动发育有不良影响，而多氟烷基物质与后代语言发育障碍有关（β系数：-1.01；95%置信区间：-1.90 至-0.11）。此外，怀孕期间接触内分泌干扰物会对 12 至 36 个月龄女孩的认知发育产生负面影响（β系数：-0.53；95%置信区间：-1.01 至-0.06）。
产前接触内分泌干扰物，尤其是金属、邻苯二甲酸酯和多氟烷基物质，与短期和长期内后代神经行为发育中断有关。此外，由于产前内分泌干扰化学物质的暴露，认知发育表现出性别差异。
