Liao Ran, Han Qing, Zhang Li
Department of Cardiovascular Medicine, Jiujiang City Key Laboratory of Cell Therapy, JiuJiang NO.1 People's Hospital, No. 48, Taling South Road, Xunyang District, Jiujiang, 332000, Jiangxi Province, People's Republic of China.
J Cardiothorac Surg. 2024 Jul 16;19(1):450. doi: 10.1186/s13019-024-02855-z.
Acute coronary syndrome (ACS) is one of the common causes of cardiovascular death. The related lncRNAs were novel approaches for early diagnosis and intervention. This paper focused on the clinical function of SNHG7 for patients after PCI.
The expression of SNHG7 was assessed in ACS patients. The predictive roles of SNHG7 were unveiled by the ROC curve. The relationship between SNHG7 and Gensini scores was judged by Pearson analysis. One-year follow-up was conducted and all patients were catalogued into different groups based on the prognosis. The qRT-PCR, K-M curve, and Cox regression analysis were performed to document the prognostic significance of SNHG7.
SNHG7 was highly expressed in ACS and its three subtypes. SNHG7 showed a certain value in predicting ACS, UA, NSTEMI, and STEMI. Gensini is a closely correlated indicator of SNHG7. The declined expression of SNHG7 was observed in the non-MACE and survival groups. The risk of MACE and death was increased in the group with high expression of SNHG7. SNHG7 was an independent biomarker in patients with ACS after PCI.
SNHG7 might be a diagnostic and prognostic tool for ACS patients.
急性冠状动脉综合征（ACS）是心血管死亡的常见原因之一。相关的长链非编码RNA是早期诊断和干预的新方法。本文聚焦于PCI术后患者中SNHG7的临床功能。
评估ACS患者中SNHG7的表达。通过ROC曲线揭示SNHG7的预测作用。采用Pearson分析判断SNHG7与Gensini评分之间的关系。进行一年随访，并根据预后将所有患者分为不同组。采用qRT-PCR、K-M曲线和Cox回归分析来证明SNHG7的预后意义。
SNHG7在ACS及其三种亚型中高表达。SNHG7在预测ACS、不稳定型心绞痛（UA）、非ST段抬高型心肌梗死（NSTEMI）和ST段抬高型心肌梗死（STEMI）方面具有一定价值。Gensini是与SNHG7密切相关的指标。在非主要不良心血管事件（MACE）和生存组中观察到SNHG7表达下降。SNHG7高表达组发生MACE和死亡的风险增加。SNHG7是PCI术后ACS患者的独立生物标志物。
SNHG7可能是ACS患者的诊断和预后工具。
