[Mechanisms of cellular multinucleation as affected by cytochalasin B in a culture of transformed fibroblasts].

The multinucleation of cytochalasin B was studied by means of phase contract microscopy and time-lapse cinematography. Several types of alteration of normal cytokineses resulted in the formation of multinucleated cells. The main way of multinucleation consists in the complete development of a cleavage furrow with the formation of daughter cells and an intercellular bridge that is followed by the fusion of these cells due to extending the entercellular bridge. These results suggest that the terminal stage of cytokinesis is the most sensitive to cytochalasin B.