Department of Orthopedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, PR China.
Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, China.
Expert Opin Drug Deliv. 2024 Jun;21(6):921-943. doi: 10.1080/17425247.2024.2379937. Epub 2024 Jul 16.
This review explores the innovative intersection of ferroptosis, a form of iron-dependent cell death, with cancer immunotherapy. Traditional cancer treatments face limitations in efficacy and specificity. Ferroptosis as a new paradigm in cancer biology, targets metabolic peculiarities of cancer cells and may potentially overcome such limitations, enhancing immunotherapy.
This review centers on the regulation of ferroptosis by nanotechnology to augment immunotherapy. It explores how nanoparticle-modulated ferroptotic cancer cells impact the TME and immune responses. The dual role of nanoparticles in modulating immune response through ferroptosis are also discussed. Additionally, it investigates how nanoparticles can be integrated with various immunotherapeutic strategies, to optimize ferroptosis induction and cancer treatment efficacy. The literature search was conducted using PubMed and Google Scholar, covering articles published up to March 2024.
The manuscript underscores the promising yet intricate landscape of ferroptosis in immunotherapy. It emphasizes the need for a nuanced understanding of ferroptosis' impact on immune cells and the TME to develop more effective cancer treatments, highlighting the potential of nanoparticles in enhancing the efficacy of ferroptosis and immunotherapy. It calls for deeper exploration into the molecular mechanisms and clinical potential of ferroptosis to fully harness its therapeutic benefits in immunotherapy.
本综述探讨了铁死亡这一新型铁依赖性细胞死亡方式与癌症免疫治疗的创新性交叉点。传统的癌症治疗在疗效和特异性方面存在局限性。铁死亡作为癌症生物学中的一种新范式，针对癌细胞的代谢特点，有可能克服这些局限性，增强免疫治疗效果。
本综述聚焦于纳米技术调控铁死亡以增强免疫治疗的作用。它探讨了纳米粒子调节的铁死亡癌细胞如何影响肿瘤微环境和免疫反应。还讨论了纳米粒子通过铁死亡调节免疫反应的双重作用。此外，还研究了纳米粒子如何与各种免疫治疗策略相结合，以优化铁死亡诱导和癌症治疗效果。文献检索使用了 PubMed 和 Google Scholar，涵盖了截至 2024 年 3 月发表的文章。
本文强调了铁死亡在免疫治疗中的有前途但复杂的前景。它强调了需要深入了解铁死亡对免疫细胞和肿瘤微环境的影响，以开发更有效的癌症治疗方法，突出了纳米粒子在增强铁死亡和免疫治疗效果方面的潜力。它呼吁深入探索铁死亡的分子机制和临床潜力，以充分利用其在免疫治疗中的治疗益处。
