Department of Cardiology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China.
Department of Emergency, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
J Cell Physiol. 2024 Nov;239(11):e31372. doi: 10.1002/jcp.31372. Epub 2024 Jul 16.
Heart failure (HF) remains prevalent in patients who survived myocardial infarction (MI). Despite the accessibility of the primary percutaneous coronary intervention and medications that alleviate ventricular remodeling with functional improvement, there is an urgent need for clinicians and basic scientists to further reveal the mechanisms behind post-MI HF as well as investigate earlier and more efficient treatment after MI. Growing numbers of studies have highlighted the crucial role of macrophages in cardiac repair and remodeling following MI, and timely intervention targeting the immune response via macrophages may represent a promising therapeutic avenue. Recently, technology such as single-cell sequencing has provided us with an updated and in-depth understanding of the role of macrophages in MI. Meanwhile, the development of biomaterials has made it possible for macrophage-targeted therapy. Thus, an overall and thorough understanding of the role of macrophages in post-MI HF and the current development status of macrophage-based therapy will assist in the further study and development of macrophage-targeted treatment for post-infarction cardiac remodeling. This review synthesizes the spatiotemporal dynamics, function, mechanism and signaling of macrophages in the process of HF after MI, as well as discusses the emerging bio-materials and possible therapeutic agents targeting macrophages for post-MI HF.
心肌梗死后心力衰竭（HF）仍然在存活的患者中普遍存在。尽管可以进行经皮冠状动脉介入治疗和药物治疗以改善心室重构和功能，但临床医生和基础科学家迫切需要进一步揭示心肌梗死后 HF 的机制，并研究 MI 后更早和更有效的治疗方法。越来越多的研究强调了巨噬细胞在 MI 后心脏修复和重构中的关键作用，通过巨噬细胞靶向免疫反应的及时干预可能代表一种有前途的治疗途径。最近，单细胞测序等技术为我们提供了对巨噬细胞在 MI 中作用的更新和深入了解。同时，生物材料的发展使得巨噬细胞靶向治疗成为可能。因此，全面深入地了解巨噬细胞在 MI 后 HF 中的作用以及基于巨噬细胞的治疗的现状，将有助于进一步研究和开发针对梗死后心脏重构的巨噬细胞靶向治疗。本综述综合了 MI 后 HF 过程中巨噬细胞的时空动力学、功能、机制和信号转导，并讨论了针对 MI 后 HF 的新兴生物材料和可能的巨噬细胞靶向治疗药物。
