Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA.
Autoimmunity. 2024 Dec;57(1):2378876. doi: 10.1080/08916934.2024.2378876. Epub 2024 Jul 16.
Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by immune system dysfunction that can lead to serious health issues and mortality. Recent investigations highlight the role of gut microbiota alterations in modulating inflammation and disease severity in SLE. This review specifically summaries the variations in gut microbiota composition across various murine models of lupus. By focusing on these differences, we aim to elucidate the intricate relationship between gut microbiota dysbiosis and the development and progression of SLE in preclinical settings.
系统性红斑狼疮（SLE）是一种自身免疫性疾病，其特征是免疫系统功能障碍，可导致严重的健康问题和死亡率。最近的研究强调了肠道微生物群改变在调节狼疮炎症和疾病严重程度中的作用。本综述专门总结了各种狼疮小鼠模型中肠道微生物群落组成的变化。通过关注这些差异，我们旨在阐明肠道微生物失调与临床前环境中 SLE 的发生和发展之间的复杂关系。
