Chero-Sandoval Lourdes, Higuera-Gómez Andrea, Martínez-Urbistondo María, Castejón Raquel, Mellor-Pita Susana, Moreno-Torres Víctor, de Luis Daniel, Cuevas-Sierra Amanda, Martínez J Alfredo
Precision Nutrition and Cardiometabolic Health, IMDEA-Food Institute (Madrid Institute for Advanced Studies), Campus of International Excellence (CEI) UAM+CSIC, Madrid, Spain.
Department of Endocrinology and Nutrition, University Clinical Hospital, University of Valladolid, Valladolid, Spain.
Eur J Clin Invest. 2025 Feb;55(2):e14339. doi: 10.1111/eci.14339. Epub 2024 Oct 28.
The relationship between systemic lupus erythematosus (SLE) and low-grade metabolic inflammation (MI) with the microbiota is crucial for understanding the pathogenesis of these diseases and developing effective therapeutic interventions. In this context, it has been observed that the gut microbiota plays a key role in the immune regulation and inflammation contributing to the exacerbation through inflammatory mediators. This research aimed to describe similarities/differences in anthropometric, biochemical, inflammatory, and hepatic markers as well as to examine the putative role of gut microbiota concerning two inflammatory conditions: SLE and MI.
Data were obtained from a cohort comprising adults with SLE and MI. Faecal samples were determined by 16S technique. Statistical analyses compared anthropometric and clinical variables, and LEfSe and MetagenomeSeq were used for metagenomic data. An interaction analysis was fitted to investigate associations of microbiota with fatty liver index (FLI) depending on the inflammatory condition.
Participants with low-grade MI showed worse values in anthropometry and biochemicals compared with patients with SLE. The liver profile of patients with MI was unhealthier, while no relevant differences were found in most of the inflammatory markers between groups. LEfSe analysis revealed an overrepresentation of Bifidobacteriaceae family in SLE group. An interactive association between gut Bifidobacterium abundance and type of disease was identified for FLI values, suggesting an effect modification of the gut microbiota concerning liver markers depending on the inflammatory condition.
This study found phenotypical and microbial similarities and disparities between these two inflammatory conditions, evidenced in clinical and hepatic markers, and showed the interactive interplay between gut Bifidobacterium and liver health (measured by FLI) that occur in a different manner depending on the type of inflammatory disease. These results underscore the importance of personalized approaches and individual microbiota in the screening of different inflammatory situations, considering unique hepatic and microbiota profiles.
系统性红斑狼疮（SLE）与低度代谢性炎症（MI）以及微生物群之间的关系对于理解这些疾病的发病机制和开发有效的治疗干预措施至关重要。在这种背景下，人们观察到肠道微生物群在免疫调节和炎症中起关键作用，通过炎症介质导致病情加重。本研究旨在描述人体测量学、生化、炎症和肝脏标志物方面的异同，并探讨肠道微生物群在两种炎症状态（SLE和MI）中的假定作用。
数据来自一个包含SLE和MI成年患者的队列。粪便样本通过16S技术进行检测。统计分析比较了人体测量学和临床变量，LEfSe和宏基因组测序用于宏基因组数据。进行了一项交互分析，以研究根据炎症状态微生物群与脂肪肝指数（FLI）之间的关联。
与SLE患者相比，低度MI患者在人体测量学和生化指标方面表现更差。MI患者的肝脏状况更不健康，而两组之间在大多数炎症标志物方面未发现相关差异。LEfSe分析显示双歧杆菌科在SLE组中占优势。对于FLI值，确定了肠道双歧杆菌丰度与疾病类型之间的交互关联，表明根据炎症状态，肠道微生物群对肝脏标志物有影响修饰作用。
本研究发现这两种炎症状态在表型和微生物方面存在相似性和差异，在临床和肝脏标志物中得到证实，并表明肠道双歧杆菌与肝脏健康（通过FLI测量）之间的交互作用根据炎症疾病类型以不同方式发生。这些结果强调了在筛查不同炎症情况时考虑个性化方法和个体微生物群的重要性，同时要考虑独特的肝脏和微生物群特征。
