Konoplitskaia K L, Pozniakova T N, Grigor'eva M V
Vopr Med Khim. 1985 Jul-Aug;31(4):39-43.
Activity of aldehyde dehydrogenase isoenzymes was studied in rat liver mitochondria and microsomes after implantation of the new antialcohol drug of the long-term effect synthesized on the basis of disulphirame. Disulphirame, both in vivo and in vitro was shown to inhibit dissimilarly these isoenzymes. The degree of sensitivity of various aldehyde dehydrogenase isoenzymes to disulphirame is important for estimation of the drug efficiency.
在植入基于双硫仑合成的新型长效抗酒精药物后，对大鼠肝脏线粒体和微粒体中的醛脱氢酶同工酶活性进行了研究。结果表明，双硫仑在体内和体外对这些同工酶的抑制作用不同。各种醛脱氢酶同工酶对双硫仑的敏感程度对于评估药物疗效很重要。
