Di Benedetto Michele, de Figueiredo Meira Gabriela, da Rocha Milena Martins, Biancardi Mariel Ruivo, Barbosa Jéssica Barroso, Câmara Jeconias, de Oliveira Paiva Neto Gerson, de Menezes Martinho Roberto Luiz, Rubira Cássia Maria Fischer, de Carvalho Sales Peres Silvia Helena
Department of Surgery Stomatology Pathology and Radiology Bauru School of Dentistry of São Paulo University FOB-USP, Alameda Dr. Octávio Pinheiro Brisolla, 9-75, Vila Regina, Bauru, SP 17012-230, Brazil.
Department of Pediatric Dentistry Orthodontics and Public Health Bauru School of Dentistry of São Paulo University FOB-USP, Alameda Dr. Octávio Pinheiro Brisolla, Block 9, Jardim Brasil, Bauru, SP 17012-901, Brazil.
Case Rep Dent. 2024 Jul 8;2024:9166581. doi: 10.1155/2024/9166581. eCollection 2024.
Proliferative verrucous leukoplakia (PVL) is an aggressive and distinct oral disorder with a high potential for malignant transformation (MT). It presents as multifocal lesions that progress over time and frequently recur, often developing carcinomas. Accurately diagnosing PVL is crucial to distinguish it from other oral mucosa lesions that have a lower risk of cancer progression. However, due to the diverse histological features observed in PVL, identifying clinical criteria and histological patterns that can be applied by unfamiliar professionals is challenging. In this study, we present a case of PVL associated with dysplasia in a 53-year-old female patient. The patient exhibited macular and leukoplakic nonscrapable lesions disseminated throughout the oral cavity, with continuous growth. The diagnosis of PVL was established during an 18-month follow-up. This case highlights the difficulties faced by both clinicians and pathologists in diagnosing PVL, emphasizing the need for careful evaluation and accurate diagnosis, particularly in patients with unusual oral lesions, and highlighting the discrepancies observed in the application of available protocols to our particular case. Distinguishing PVL from similar conditions can be challenging due to overlapping clinical signs and indistinct histopathological features.
增殖性疣状白斑（PVL）是一种侵袭性且独特的口腔疾病，具有较高的恶变潜能。它表现为多灶性病变，随时间进展且频繁复发，常发展为癌。准确诊断PVL对于将其与其他癌症进展风险较低的口腔黏膜病变区分开来至关重要。然而，由于PVL中观察到的组织学特征多样，确定不熟悉该领域的专业人员可应用的临床标准和组织学模式具有挑战性。在本研究中，我们报告了一例53岁女性患者的PVL伴发育异常病例。该患者口腔内出现散在的黄斑和不可刮除的白斑病变，且持续生长。PVL的诊断在18个月的随访期间得以确立。该病例突出了临床医生和病理学家在诊断PVL时面临的困难，强调了仔细评估和准确诊断的必要性，尤其是在患有不寻常口腔病变的患者中，并突出了在将现有方案应用于我们的特定病例时观察到的差异。由于临床体征重叠和组织病理学特征不明确，将PVL与类似病症区分开来可能具有挑战性。
