Geismann Florian, Brueckner Kathleen, Pfeifer Michael, Salzberger Bernd, Bauernfeind Stilla, Hitzenbichler Florian, Simon Michaela, Caplunik-Pratsch Aila, Schneider-Brachert Wulf, Wiest Clemens, Hinterberger Thilo, Ruegamer Tamara, Mohr Arno
Center for Pneumonology, Donaustauf Hospital, Donaustauf, Germany.
Department of Internal Medicine 2, University Hospital Regensburg, Regensburg, Germany.
Biomed Hub. 2024 May 20;9(1):67-72. doi: 10.1159/000537770. eCollection 2024 Jan-Dec.
Invasive pneumococcal disease is a major cause of morbidity and mortality in infectious diseases. Selective reporting of antibiotic susceptibility test results might lead to a tailored antibiotic therapy and could therefore be an important antibiotic stewardship program intervention. The aim of this study was to analyse whether a switch to selective reporting of antibiotic test results leads to a more focused antibiotic therapy in patients with a bloodstream infection with .
This study was performed as a retrospective cohort study at the University Hospital Regensburg, Germany. All blood cultures positive for between 2006 and 2021 were analysed. In 2014, a switch to selective reporting of antibiotic susceptibility test results omitting sensitivity results for agents not recommended was introduced.
Twenty-four hours after final antibiotic susceptibility test results were available, 20.9% before (BI) versus 15.4% after implementation (AI) of selective reporting of antibiotic test results received a narrow-spectrum penicillin, while only 2.3% BI versus 5.8% AI received a narrow-spectrum penicillin from the beginning.
Selective reporting of antibiotic susceptibility test results without further antimicrobial stewardship interventions did not lead to a higher use of a narrow-spectrum penicillin in this study.
侵袭性肺炎球菌病是传染病发病和死亡的主要原因。选择性报告抗生素敏感性试验结果可能会带来针对性的抗生素治疗，因此可能是抗生素管理计划的一项重要干预措施。本研究的目的是分析转向选择性报告抗生素试验结果是否会使血流感染患者接受更有针对性的抗生素治疗。
本研究在德国雷根斯堡大学医院进行，采用回顾性队列研究。分析了2006年至2021年间所有血培养阳性的情况。2014年，引入了选择性报告抗生素敏感性试验结果的方法，省略了对不推荐药物的敏感性结果。
在获得最终抗生素敏感性试验结果24小时后，在选择性报告抗生素试验结果实施前（BI）有20.9%的患者接受窄谱青霉素治疗，实施后（AI）为15.4%，而从一开始就接受窄谱青霉素治疗的患者在BI时仅为2.3%，AI时为5.8%。
在本研究中，在没有进一步抗菌药物管理干预的情况下，选择性报告抗生素敏感性试验结果并未导致窄谱青霉素的使用增加。
