Yu Dong, Lu Zhaoyu, Chong Yang
Department of Traditional Chinese Medicine, The Affiliated Hospital of Yangzhou University, Yangzhou University, No. 368 Hanjiang Middle Road, Yangzhou 225000, Jiangsu, China.
Department of General Surgery, The Affiliated Hospital of Yangzhou University, Yangzhou University, No. 368 Hanjiang Middle Road, Yangzhou 225000, Jiangsu, China.
Burns Trauma. 2024 Jul 16;12:tkae022. doi: 10.1093/burnst/tkae022. eCollection 2024.
Integrins are heterodimers composed of α and β subunits that are bonded through non-covalent interactions. Integrins mediate the dynamic connection between extracellular adhesion molecules and the intracellular actin cytoskeleton. Integrins are present in various tissues and organs where these heterodimers participate in diverse physiological and pathological responses at the molecular level in living organisms. Wound healing is a crucial process in the recovery from traumatic diseases and comprises three overlapping phases: inflammation, proliferation and remodeling. Integrins are regulated during the entire wound healing process to enhance processes such as inflammation, angiogenesis and re-epithelialization. Prolonged inflammation may result in failure of wound healing, leading to conditions such as chronic wounds. Bacterial colonization of a wound is one of the primary causes of chronic wounds. Integrins facilitate the infectious effects of bacteria on the host organism, leading to chronic inflammation, bacterial colonization, and ultimately, the failure of wound healing. The present study investigated the role of integrins as bridges for bacteria-cell interactions during wound healing, evaluated the role of integrins as nodes for bacterial inhibition during chronic wound formation, and discussed the challenges and prospects of using integrins as therapeutic targets in wound healing.
整合素是由α和β亚基组成的异二聚体，通过非共价相互作用结合在一起。整合素介导细胞外黏附分子与细胞内肌动蛋白细胞骨架之间的动态连接。整合素存在于各种组织和器官中，这些异二聚体在生物体的分子水平上参与多种生理和病理反应。伤口愈合是创伤性疾病恢复过程中的一个关键过程，包括三个重叠阶段：炎症、增殖和重塑。在整个伤口愈合过程中，整合素受到调节，以促进炎症、血管生成和重新上皮化等过程。炎症持续时间过长可能导致伤口愈合失败，引发慢性伤口等情况。伤口的细菌定植是慢性伤口的主要原因之一。整合素促进细菌对宿主生物体的感染作用，导致慢性炎症、细菌定植，并最终导致伤口愈合失败。本研究调查了整合素在伤口愈合过程中作为细菌-细胞相互作用桥梁的作用，评估了整合素在慢性伤口形成过程中作为细菌抑制节点的作用，并讨论了将整合素用作伤口愈合治疗靶点的挑战和前景。
