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肠系膜脂膜炎

Mesenteric Panniculitis.

作者信息

Ibrahim Mohamad Ali, El Kouzi Zakaria, El Mokahal Ali, Omran Nadine, Muallem Nadim, Sharara Ala I

机构信息

Division of Gastroenterology, Clemenceau Medical Center, Dubai, United Arab Emirates.

Division of Gastroenterology, American University of Beirut Medical Center, Beirut, Lebanon.

出版信息

Inflamm Intest Dis. 2024 May 22;9(1):157-164. doi: 10.1159/000539432. eCollection 2024 Jan-Dec.

DOI:10.1159/000539432
PMID:39015257
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11250460/
Abstract

BACKGROUND

Mesenteric panniculitis (MP) is an uncommon non-neoplastic idiopathic inflammation of adipose tissue, mainly affecting the mesentery of the small intestine, with its etiology remaining largely speculative. The difference in prevalence of MP among females and males varies across multiple studies. In most cases, MP is asymptomatic; however, patients can present with nonspecific abdominal symptoms or can mimic underlying gastrointestinal and abdominal diseases. The diagnosis is suggested by computed tomography and is usually confirmed by surgical biopsies if necessary. Treatment is generally supportive and based on a few selected drugs, namely, nonsteroidal anti-inflammatory drugs or corticosteroids. Surgery is reserved when the diagnosis is unclear, when malignancy is suspected or in the case of severe presentation such as mass effect, bowel obstruction, or ischemic changes.

SUMMARY

MP is a rare inflammatory condition of the mesentery often asymptomatic but can cause nonspecific abdominal symptoms. Diagnosis relies on computed tomography imaging, with treatment mainly supportive, utilizing medications like nonsteroidal anti-inflammatory drugs or corticosteroids, while surgery is reserved for severe cases or diagnostic uncertainty.

KEY MESSAGES

MP causes abdominal pain, and it is mainly diagnosed with CT scan.

摘要

背景

肠系膜脂膜炎(MP)是一种罕见的非肿瘤性特发性脂肪组织炎症,主要累及小肠系膜,其病因在很大程度上仍属推测。多项研究中,MP在女性和男性中的患病率差异各不相同。大多数情况下,MP无症状;然而,患者可能出现非特异性腹部症状,或可类似潜在的胃肠道和腹部疾病。通过计算机断层扫描提示诊断,如有必要通常通过手术活检确诊。治疗一般为支持性治疗,并基于少数几种选定药物,即非甾体抗炎药或皮质类固醇。当诊断不明确、怀疑恶性肿瘤或出现严重表现如肿块效应、肠梗阻或缺血性改变时,则需进行手术。

总结

MP是一种罕见的肠系膜炎症性疾病,通常无症状,但可引起非特异性腹部症状。诊断依赖计算机断层扫描成像,治疗主要为支持性治疗,使用非甾体抗炎药或皮质类固醇等药物,而手术则用于严重病例或诊断不确定的情况。

关键信息

MP可引起腹痛,主要通过CT扫描诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca27/11250460/19f67eb28680/iid-2024-0009-0001-539432_F02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca27/11250460/ace8281afa4e/iid-2024-0009-0001-539432_F01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca27/11250460/19f67eb28680/iid-2024-0009-0001-539432_F02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca27/11250460/ace8281afa4e/iid-2024-0009-0001-539432_F01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca27/11250460/19f67eb28680/iid-2024-0009-0001-539432_F02.jpg

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本文引用的文献

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A Clinical Review of Mesenteric Panniculitis.肠系膜脂膜炎的临床综述
Gastroenterol Hepatol (N Y). 2023 Apr;19(4):211-218.
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Drugs That Interact With Colchicine Via Inhibition of Cytochrome P450 3A4 and P-Glycoprotein: A Signal Detection Analysis Using a Database of Spontaneously Reported Adverse Events (FAERS).通过抑制细胞色素P450 3A4和P-糖蛋白与秋水仙碱相互作用的药物:使用自发报告不良事件数据库(FAERS)进行信号检测分析
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Mesenteric panniculitis various presentations and management: A single institute ten years, experience.
肠系膜脂膜炎的多种表现及管理:一家机构十年的经验
Ann Med Surg (Lond). 2022 Jul 16;80:104203. doi: 10.1016/j.amsu.2022.104203. eCollection 2022 Aug.
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Mesenteric Panniculitis, Sclerosing Mesenteritis and Mesenteric Lipodystrophy: Descriptive Review of a Rare Condition.肠系膜脂膜炎、硬化性肠系膜炎和肠系膜脂肪营养不良:一种罕见疾病的描述性综述
Clin Colon Rectal Surg. 2022 Aug 10;35(4):342-348. doi: 10.1055/s-0042-1743588. eCollection 2022 Jul.
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Mesenteric panniculitis is associated with cardiovascular risk-factors: A case-control study.肠系膜脂膜炎与心血管风险因素相关:一项病例对照研究。
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CT features associated with underlying malignancy in patients with diagnosed mesenteric panniculitis.肠系膜脂膜炎患者伴发基础恶性肿瘤的 CT 特征。
Diagn Interv Imaging. 2022 Sep;103(9):394-400. doi: 10.1016/j.diii.2022.06.009. Epub 2022 Jul 15.
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Mesenteric panniculitis does not confer an increased risk for cancers: A systematic review and meta-analysis.肠系膜脂膜炎并不会增加癌症的风险:系统评价和荟萃分析。
Medicine (Baltimore). 2022 Apr 29;101(17):e29143. doi: 10.1097/MD.0000000000029143.
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Colchicine as an Alternative First-Line Treatment of Sclerosing Mesenteritis: A Retrospective Study.秋水仙碱作为肠系膜硬化症一线治疗的选择:一项回顾性研究。
Dig Dis Sci. 2022 Jun;67(6):2403-2412. doi: 10.1007/s10620-021-07081-4. Epub 2021 Jun 4.
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Clinical and radiological features of mesenteric panniculitis: a critical overview.肠系膜脂膜炎的临床和影像学特征:批判性综述。
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Relationship of mesenteric panniculitis with visceral and subcutaneous adipose tissue.肠系膜脂膜炎与内脏和皮下脂肪组织的关系。
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