Gögebakan Özlem, Osterhoff Martin A, Albrecht Thomas
Department for Radiology and Interventional Therapy, Vivantes Klinikum Neukölln, Berlin, Germany.
CBF, Department for Endocrinology, Diabetes and Nutrition, Charité - Univesrsitätsmedizin Berlin, Germany.
Rofo. 2018 Nov;190(11):1044-1052. doi: 10.1055/a-0633-3558. Epub 2018 Sep 6.
Mesenteric panniculitis (MP) is histologically characterized by chronic nonspecific inflammation of the adipose tissue of the intestinal mesentery with unclear etiology. MP occurs predominantly in men, mostly in mid to late adulthood. MP is typically found as an incidental diagnosis on abdominal CT.
A comprehensive review of the literature including case reports and cohort studies was performed. Therefore, a global search in PubMed was carried out. Search terms were (and/or) "mesenteric panniculitis", "panniculitis mesenterialis", "mesenteric lymph nodes", "CT", "imaging", "sclerosing mesenteritis", "case report", "therapy".
MP is a relatively common CT finding. The true prevalence seems to be higher than the reported 0.6 % to 2.4 % due to underreporting. The most important differential diagnosis is malignant lymphoma, which may be difficult to distinguish from MP. The majority of patients with MP are clinically asymptomatic and do not require therapy. In rare symptomatic cases, non-specific symptoms like abdominal pain, fever, nausea or vomiting occur. For therapy, glucocorticoids and tamoxifen have been suggested. Several studies suggested that MP is associated with other diseases and might be a paraneoplastic phenomenon, but four recently published case-control studies suggest that MP is an independent non-specific benign age-related phenomenon. However, two further studies show a possible association of MP with malignant lymphoma. The clinical relevance of MP remains the subject of scientific debate.
· Mesenteric panniculitis (MP) is a non-specific, chronic inflammation of the mesenteric adipose tissue with characteristic CT signs. · MP is a relatively common incidental finding on abdominal CT. · Malignant lymphoma is the main differential diagnosis. · An association of MP with other diseases including malignancy has been discussed but cannot be confirmed unequivocally. · MP is rarely symptomatic with fever, nausea, vomiting, abdominal pain, or diarrhea.
· Gögebakan Ö, Osterhoff MA, Albrecht T. Mesenteric Panniculitis (MP): A Frequent Coincidental CT Finding of Debatable Clinical Significance. Fortschr Röntgenstr 2018; 190: 1044 - 1052.
肠系膜脂膜炎（MP）的组织学特征为肠系膜脂肪组织的慢性非特异性炎症，病因不明。MP主要发生于男性，多在成年中晚期。MP通常是在腹部CT检查时偶然发现。
对包括病例报告和队列研究在内的文献进行全面综述。因此，在PubMed上进行了全面检索。检索词为（和/或）“肠系膜脂膜炎”、“肠系膜性脂膜炎”、“肠系膜淋巴结”、“CT”、“影像学”、“硬化性肠系膜炎”、“病例报告”、“治疗”。
MP是一种相对常见的CT表现。由于报告不足，其实际患病率似乎高于报道的0.6%至2.4%。最重要的鉴别诊断是恶性淋巴瘤，可能难以与MP区分。大多数MP患者临床上无症状，无需治疗。在罕见的有症状病例中，会出现腹痛、发热、恶心或呕吐等非特异性症状。对于治疗，有人建议使用糖皮质激素和他莫昔芬。多项研究表明MP与其他疾病有关，可能是一种副肿瘤现象，但最近发表的四项病例对照研究表明MP是一种独立的、非特异性的、与年龄相关的良性现象。然而，另外两项研究显示MP与恶性淋巴瘤可能有关。MP的临床相关性仍是科学争论的主题。
·肠系膜脂膜炎（MP）是肠系膜脂肪组织的一种非特异性慢性炎症，具有特征性CT表现。·MP是腹部CT上相对常见的偶然发现。·恶性淋巴瘤是主要的鉴别诊断。·已讨论了MP与包括恶性肿瘤在内的其他疾病的关联，但不能明确证实。·MP很少出现发热、恶心、呕吐、腹痛或腹泻等症状。
·Gögebakan Ö, Osterhoff MA, Albrecht T. Mesenteric Panniculitis (MP): A Frequent Coincidental CT Finding of Debatable Clinical Significance. Fortschr Röntgenstr 2018; 190: 1044 - 1052.
