开拓喹唑啉酮-富勒烯吡咯烷纳米杂化物的光活性相关性以解决癌症化疗耐药性问题
Pioneering the Photoactive Relevance of Quinazolinone-Fullereropyrrolidine Nanohybrids To Address Chemotherapeutic Resistance in Cancer.
作者信息
Sengupta Devashish, Sharma Debdulal, Das Ranjan Kumar, Das Prem, Halder Madhumanti, Rai Pushkar, Chakrabarti Oishee
机构信息
Department of Chemistry, Assam University, Silchar-788011, Assam, India.
Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, Kolkata-700064, West Bengal, India.
出版信息
ACS Med Chem Lett. 2024 Jun 24;15(7):1118-1126. doi: 10.1021/acsmedchemlett.4c00187. eCollection 2024 Jul 11.
This study investigates the impact of C and C fullerenes on quinazolinone, specifically in quinazolinone-fulleropyrrolidine nanohybrids. The nanohybrids and exhibit distinct spectral shifts and have significant photobiological antineoplastic properties. enhances apoptosis, while reduces Cyclin A levels and counteracts oncogenic effects by promoting cell differentiation. demonstrates heightened cytotoxicity by overcoming chemotherapy resistance by modulating and levels. This innovative approach, distinguishing between C and C, represents a novel contribution to the existing scientific literature.
本研究调查了C和C富勒烯对喹唑啉酮的影响，特别是在喹唑啉酮-富勒吡咯烷纳米杂化物中的影响。这些纳米杂化物表现出明显的光谱位移，并具有显著的光生物抗肿瘤特性。 增强细胞凋亡，而 降低细胞周期蛋白A水平并通过促进细胞分化来对抗致癌作用。 通过调节 和 水平克服化疗耐药性，表现出更高的细胞毒性。这种区分C和C的创新方法是对现有科学文献的新贡献。
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