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富勒烯治疗癌症:一种新兴的工具。

Fullerenes for the treatment of cancer: an emerging tool.

机构信息

Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, 576104, Udupi, Karnataka, India.

Department of Pharmaceutics, Goa College of Pharmacy, 18th June Road, Panaji, 403 001, Goa, India.

出版信息

Environ Sci Pollut Res Int. 2022 Aug;29(39):58607-58627. doi: 10.1007/s11356-022-21449-7. Epub 2022 Jul 6.

Abstract

Cancer is a most common cause of mortality globally. Available medicines possess severe side effects owing to their non-specific targeting. Hence, there is a need of an alternative in the healthcare system that should have high efficacy with the least side effects, also having the ability to achieve site-specific targeting and be reproducible. This is possible with the help of fullerenes. Fullerenes are having the unique physicochemical and photosensitizer properties. This article discusses the synthesis, functionalization, mechanism, various properties, and applications of C60 fullerenes in the treatment of cancer. The review article also addresses the various factors influencing the activity of fullerenes including the environmental conditions, toxicity profile, and future prospective.

摘要

癌症是全球最常见的死亡原因。现有的药物由于其非特异性靶向而具有严重的副作用。因此,医疗保健系统需要一种具有高效性和最小副作用的替代品,同时还具有实现特定部位靶向和可重现性的能力。这可以借助富勒烯来实现。富勒烯具有独特的物理化学和光敏剂特性。本文讨论了 C60 富勒烯在癌症治疗中的合成、功能化、机制、各种性质和应用。这篇综述文章还讨论了影响富勒烯活性的各种因素,包括环境条件、毒性概况和未来前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95be/9399030/88dff0062a26/11356_2022_21449_Fig1_HTML.jpg

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