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一例因便秘就诊发现的15厘米大的他莫昔芬相关子宫内膜息肉：病例报告及文献复习

Fifteen-Centimeter Giant Tamoxifen-Associated Endometrial Polyp Presenting With Constipation: A Case Report and Review of the Literature.

作者信息

Apornvirat Sompon, Suwannarurk Komsun

机构信息

Department of Pathology Thammasat University Hospital, Pathum Thani, Thailand.

Chulabhorn International College of Medicine Thammasat University, Pathum Thani, Thailand.

出版信息

Case Rep Obstet Gynecol. 2024 Jul 8;2024:9826447. doi: 10.1155/2024/9826447. eCollection 2024.

DOI:10.1155/2024/9826447
PMID:39015508
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11250697/
Abstract

Endometrial polyps are benign disorganized growth of endometrial glands and stroma in the uterine cavity. They are associated with subfertility, abnormal uterine bleeding, and tamoxifen use. While most polyps are smaller than 2 cm in size, rare giant polyps can cause concerns over malignancy. We report a case of a 15 cm giant endometrial polyp in a 58-year-old woman with a history of tamoxifen use who presented with an uncommon complaint of constipation. Additionally, a literature review of giant endometrial polyp cases is presented. This case represents the largest reported endometrial polyp to date.

摘要

子宫内膜息肉是子宫腔内子宫内膜腺体和间质的良性杂乱生长。它们与生育力低下、异常子宫出血以及他莫昔芬的使用有关。虽然大多数息肉大小小于2厘米，但罕见的巨大息肉可能会引发对恶性肿瘤的担忧。我们报告一例58岁有他莫昔芬使用史的女性患者，其患有一个15厘米的巨大子宫内膜息肉，该患者以罕见的便秘主诉就诊。此外，还对巨大子宫内膜息肉病例进行了文献综述。该病例是迄今为止报道的最大的子宫内膜息肉。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d119/11250697/80c991a72e9d/CRIOG2024-9826447.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d119/11250697/13bbb8cc6d81/CRIOG2024-9826447.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d119/11250697/565004fe095a/CRIOG2024-9826447.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d119/11250697/e55bd55ea493/CRIOG2024-9826447.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d119/11250697/80c991a72e9d/CRIOG2024-9826447.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d119/11250697/13bbb8cc6d81/CRIOG2024-9826447.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d119/11250697/565004fe095a/CRIOG2024-9826447.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d119/11250697/e55bd55ea493/CRIOG2024-9826447.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d119/11250697/80c991a72e9d/CRIOG2024-9826447.004.jpg

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本文引用的文献

1
Evaluation of a Patient With Non-Myoinvasive Uterine Serous Carcinoma Confined to a Polyp and Positive Peritoneal Washings With Somatic ARHGAP35 and KRAS Mutations.对一名非肌层浸润性子宫浆液性癌局限于息肉且腹膜冲洗液中存在体细胞ARHGAP35和KRAS突变的患者的评估。
Cureus. 2022 Jul 8;14(7):e26663. doi: 10.7759/cureus.26663. eCollection 2022 Jul.
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Endometrial polyps. An evidence-based diagnosis and management guide.子宫内膜息肉。循证诊断与管理指南。
Eur J Obstet Gynecol Reprod Biol. 2021 May;260:70-77. doi: 10.1016/j.ejogrb.2021.03.017. Epub 2021 Mar 13.
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Giant Endometrial Polyp in a Postmenopausal Woman.
绝经后女性的巨大子宫内膜息肉
Cureus. 2021 Jan 19;13(1):e12789. doi: 10.7759/cureus.12789.
4
Case report of atypical endometrial stromal cells in an endometrial polyp and osteoclastic like giant cells in leiomyoma in the same patient: Is it a coincidence or is it a result of Tamoxifen treatment?同一患者子宫内膜息肉中出现非典型子宫内膜间质细胞和平滑肌瘤中出现破骨细胞样巨细胞的病例报告：这是巧合还是他莫昔芬治疗的结果？
Acta Biomed. 2019 Mar 21;90(4):572-576. doi: 10.23750/abm.v90i4.7746.
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Distant recurrence in a patient with polyp-confined stage IA serous endometrial carcinoma treated with adjuvant chemotherapy: A case report and review of literature.息肉局限的IA期浆液性子宫内膜癌患者接受辅助化疗后的远处复发：一例病例报告及文献复习
Gynecol Oncol Rep. 2019 Nov 5;31:100512. doi: 10.1016/j.gore.2019.100512. eCollection 2020 Feb.
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Endometrial polyps: Pathogenesis, sequelae and treatment.子宫内膜息肉：发病机制、后遗症及治疗
SAGE Open Med. 2019 May 2;7:2050312119848247. doi: 10.1177/2050312119848247. eCollection 2019.
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Giant Endometrial Polyp: An Enigma in a Postmenopausal Woman.巨大子宫内膜息肉：绝经后女性中的一个谜团。
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Hysteroscopy for treating subfertility associated with suspected major uterine cavity abnormalities.宫腔镜检查用于治疗与疑似子宫腔主要异常相关的不孕症。
Cochrane Database Syst Rev. 2018 Dec 5;12(12):CD009461. doi: 10.1002/14651858.CD009461.pub4.
9
Endometrial Stromal Sarcoma Arising from Endometrial Polyp: A Case Report.起源于子宫内膜息肉的子宫内膜间质肉瘤：一例报告
Kobe J Med Sci. 2018 Sep 11;64(2):E36-E42.
10
An Elongated Endometrial Polyp Prolapsing Through the Introitus in a Virgin.
Gynecol Minim Invasive Ther. 2018 Apr-Jun;7(2):78-80. doi: 10.4103/GMIT.GMIT_21_18. Epub 2018 May 2.