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A Multi-Centre, Single-Arm Clinical Study to Confirm Safety and Performance of PuraStat®, for the Management of Bleeding in Elective Carotid Artery Surgery.多中心、单臂临床研究，旨在确认 PuraStat®在择期颈动脉手术中管理出血的安全性和性能。
Clin Appl Thromb Hemost. 2022 Jan-Dec;28:10760296221144307. doi: 10.1177/10760296221144307.
2
Facelift Patients Receiving Intraoperative Administration of a Self-assembling Hemostat Agent Experienced Minimal Bruising and No Acute Hematomas: A Pilot Study.接受术中自组装止血剂给药的面部提升患者瘀伤轻微且无急性血肿：一项初步研究。
Aesthet Surg J Open Forum. 2022 Apr 29;4:ojac037. doi: 10.1093/asjof/ojac037. eCollection 2022.
3
The Use of Self-Assembling Peptides (PuraStat™) in Functional Endoscopic Sinus Surgery for Haemostasis and Reducing Adhesion Formation. A Case Series of 94 Patients.自组装肽（PuraStat™）在功能性鼻内镜鼻窦手术中用于止血和减少粘连形成的应用。94例患者的病例系列
Surg Technol Int. 2022 Nov 15;41:105-110. doi: 10.52198/22.STI.41.GS1694.
4
Clinical Use of the Self-Assembling Peptide RADA16: A Review of Current and Future Trends in Biomedicine.自组装肽RADA16的临床应用：生物医学当前及未来趋势综述
Front Bioeng Biotechnol. 2021 Jun 2;9:679525. doi: 10.3389/fbioe.2021.679525. eCollection 2021.
5
PuraStat in gastrointestinal bleeding: results of a prospective multicentre observational pilot study.普拉斯塔特在胃肠道出血中的应用：一项前瞻性多中心观察性试点研究结果。
Surg Endosc. 2022 May;36(5):2954-2961. doi: 10.1007/s00464-021-08589-6. Epub 2021 Jun 15.
6
Use of Purastat, a novel haemostatic matrix based on self-assembling peptides in the prevention of nasopharyngeal adhesion formation.使用Purastat，一种基于自组装肽的新型止血基质预防鼻咽粘连形成。
Int J Surg Case Rep. 2020;70:227-229. doi: 10.1016/j.ijscr.2020.04.027. Epub 2020 May 8.
7
Haemostasis and prevention of bleeding related to ER: The role of a novel self-assembling peptide.止血和预防 ER 相关出血：新型自组装肽的作用。
United European Gastroenterol J. 2019 Feb;7(1):155-162. doi: 10.1177/2050640618811504. Epub 2018 Nov 5.
8
Feasibility of a novel, synthetic, self-assembling peptide for suture-line haemostasis in cardiac surgery.一种新型合成自组装肽用于心脏手术缝合线止血的可行性
J Cardiothorac Surg. 2018 Jun 15;13(1):68. doi: 10.1186/s13019-018-0745-2.
9
A novel haemostatic agent based on self-assembling peptides in the setting of nasal endoscopic surgery, a case series.基于自组装肽的新型止血剂在鼻内镜手术中的应用：病例系列
Int J Surg Case Rep. 2017 Nov 20;41:461-464. doi: 10.1016/j.ijscr.2017.11.024. eCollection 2017.
10
Lateral SMASectomy, plication and short scar facelifts: indications and techniques.外侧SMAS切除术、折叠术及短切口面部提升术：适应症与技术
Clin Plast Surg. 2008 Oct;35(4):533-50, vi. doi: 10.1016/j.cps.2008.06.003.

新型自组装RADA-16肽基质在当前耳鼻喉科的应用

Current otolaryngologic applications of the novel self-assembling RADA-16 peptide matrix.

作者信息

Pak Kaitlynne Y, Tang Dennis M, Sreenath Satyan B, Ito Christopher J, Senior Brent A, Lam Kent K, Higgins Thomas S, Hur Kevin, Tam Benjamin, Khalid Ayesha N, Wu Arthur W

机构信息

Division of Otolaryngology-Head & Neck Surgery Cedars-Sinai Medical Center Los Angeles USA.

Department of Otolaryngology-Head & Neck Surgery Indiana University Bloomington USA.

出版信息

Laryngoscope Investig Otolaryngol. 2024 Jul 16;9(4):e1299. doi: 10.1002/lio2.1299. eCollection 2024 Aug.

DOI:10.1002/lio2.1299
PMID:39015551
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11250146/
Abstract

A novel bioresorbable agent on the market is PuraGel® (3-D Matrix, Tokyo, Japan), a RADA-16 product that acts as a synthetic hemostatic and space-filling gel that promotes wound healing and prevents adhesion formation. Given the reported benefits of accelerated wound healing and scar tissue prevention, there are multiple otolaryngologic applications where RADA-16 might improve outcomes. Our study highlights current utilization and associated post-operative complications with this product.

摘要

市场上一种新型的可生物吸收剂是PuraGel®（3-D Matrix，东京，日本），它是一种RADA-16产品，作为一种合成的止血和填充空间的凝胶，可促进伤口愈合并防止粘连形成。鉴于有报道称其具有加速伤口愈合和预防瘢痕组织形成的益处，在多个耳鼻喉科应用中，RADA-16可能会改善治疗效果。我们的研究强调了该产品目前的使用情况及相关的术后并发症。