Lee M F, Ma Z, Ananda A
Royal Prince Alfred Hospital, 50 Missenden Rd, Camperdown, NSW, 2050, Australia.
Int J Surg Case Rep. 2017 Nov 20;41:461-464. doi: 10.1016/j.ijscr.2017.11.024. eCollection 2017.
Recently, a novel purely synthetic topical haemostatic agent (PuraStat) has been proposed in surgery based on the self-assembling tendency of some repeating peptide sequences. This transparent, ready to use hydrogel appears suitable for use in FEES with low rates of post-operative re-bleeding and adhesion formation.A first series of 60 patients experiencing endonasal powered turbinoplasty across various hospitals in Sydney using PuraStat was observed for postoperative re-bleeding and adhesion formation.
In all 60 patients, no post-operative re-bleeding was observed, while healing went well in absence of adhesion formation. Effective haemostasis with PuraStat is well documented in other surgical fields, but its use in FEES and adhesion prevention is relatively novel.
Synthetic self-assembling peptides appear to be indicated in this area. Further studies are needed to confirm their potential for adhesion prevention.
最近，基于一些重复肽序列的自组装倾向，一种新型的纯合成局部止血剂（PuraStat）已被应用于外科手术中。这种透明、即用型水凝胶似乎适用于功能性鼻内镜鼻窦手术（FEES），术后再出血率和粘连形成率较低。观察了悉尼各医院使用PuraStat进行鼻内动力鼻甲成形术的首批60例患者的术后再出血和粘连形成情况。
在所有60例患者中，均未观察到术后再出血，且愈合良好，未形成粘连。PuraStat在其他外科领域的有效止血已有充分记录，但其在功能性鼻内镜鼻窦手术和预防粘连方面的应用相对较新。
合成自组装肽似乎适用于该领域。需要进一步研究以证实其预防粘连的潜力。
