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高剂量咖啡因诱发脑梗死导致一名年轻成人出现部分闭锁综合征：一种新的关联？

High Doses of Caffeine-Induced Cerebral Infarction Leading to Partial Locked-In Syndrome in a Young Adult: A Novel Association?

作者信息

Sinha Vijay, Lam Loc, Nguyen Michael V

机构信息

TIRR Memorial Hermann Rehabilitation and Research, Houston, TX, USA.

H. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA.

出版信息

Case Rep Neurol. 2024 Apr 23;16(1):115-121. doi: 10.1159/000538950. eCollection 2024 Jan-Dec.

DOI:10.1159/000538950
PMID:39015836
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11250471/
Abstract

INTRODUCTION

This is a case of a 30-year-old male with no prior medical conditions presented to the emergency department for presumed seizures after ingesting 900 mg of caffeine via pre-workout drinks and pills.

CASE PRESENTATION

The patient was described as having nearly 15 min of generalized seizure activity observed by emergency medical service, requiring midazolam. A head computerized tomography (CT) demonstrated a possible thrombus, and further, CT angiography and CT perfusion confirmed a basilar artery occlusion. He was treated with tissue plasminogen activator and underwent thrombectomy achieving TICI grade 3 in the left posterior cerebral artery and TICI grade 2b in the superior cerebellar artery. Unfortunately, the patient experienced a hemorrhagic conversion leading to an incomplete locked-in syndrome.

CONCLUSION

This case report suggests a novel association between energy drinks and caffeine supplements as potential etiologies for rapid onset on cerebrovascular incidents.

摘要

引言

这是一例30岁男性病例，既往无病史，因通过运动前饮料和药丸摄入900毫克咖啡因后疑似癫痫发作而被送往急诊科。

病例介绍

据描述，患者出现了近15分钟的全身性癫痫活动，急诊医疗服务人员观察到这一情况，需要使用咪达唑仑。头部计算机断层扫描（CT）显示可能存在血栓，进一步的CT血管造影和CT灌注检查证实基底动脉闭塞。他接受了组织型纤溶酶原激活剂治疗，并接受了血栓切除术，左大脑后动脉达到脑梗死溶栓分级（TICI）3级，小脑上动脉达到TICI 2b级。不幸的是，患者发生了出血性转化，导致不完全闭锁综合征。

结论

本病例报告提示能量饮料和咖啡因补充剂之间存在一种新的关联，可能是脑血管事件快速发作的潜在病因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce6/11250471/5e678797421d/crn-2024-0016-0001-538950_F04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce6/11250471/98fdaa2f7637/crn-2024-0016-0001-538950_F01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce6/11250471/b9397a7600fc/crn-2024-0016-0001-538950_F02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce6/11250471/a8a192e3213f/crn-2024-0016-0001-538950_F03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce6/11250471/5e678797421d/crn-2024-0016-0001-538950_F04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce6/11250471/98fdaa2f7637/crn-2024-0016-0001-538950_F01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce6/11250471/b9397a7600fc/crn-2024-0016-0001-538950_F02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce6/11250471/a8a192e3213f/crn-2024-0016-0001-538950_F03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bce6/11250471/5e678797421d/crn-2024-0016-0001-538950_F04.jpg

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